Evidence map›Paper›PMID 41397685›Full record

Trial reportBJOG : an international journal of obstetrics and gynaecology2026

The Use of First-Void Urine to Screen Women Aged 60-79 for HPV in the UK: The Catch-Up Screen Study.

Christine Rake, Emma J Davidson, Alex Young, Annelie Maskell, Jennifer C Davies, Marina Flynn, Sofia Vidali, Hannah Mohy-Eldin, Jiexin Cao, Belinda Nedjai and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christine RakeFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Emma J DavidsonGynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-0284-8630
Alex YoungHull-York Medical School, University of Hull, Hull, UK.
Annelie MaskellGynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Jennifer C DaviesGynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-0193-0053
Marina FlynnHull and East Yorkshire Hospitals NHS Trust, Hull, UK.
Sofia VidaliWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Hannah Mohy-EldinWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Jiexin CaoGynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Belinda NedjaiWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Una MacleodHull-York Medical School, University of Hull, Hull, UK.
Julian PetoFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Clare GilhamFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-9477-6090

Funding

Yorkshire Cancer Research
6 · The paper itself

Abstract

objectiveAlmost half the deaths from cervical cancer in the UK are among women aged over 65 who were already above the upper age of screening when primary HPV screening was introduced in the UK in 2019. Our aim is to test the feasibility of a national catch-up HPV testing programme.

designThis first phase of the Catch-Up Screen study involved randomizing over 3000 invited participants to receive a urine HPV test and a follow-up telephone call or text message.

settingGP practices in Hull and Manchester, UK. POPULATION: Women aged 60-79 who have not undergone primary HPV screening.

methodsEligible women were selected from GP practice records, and 3074 were invited to provide an at-home first-void urine sample for HPV testing.

main outcome measuresUptake of at-home urine screening according to screening history, area-level index of deprivation, and randomised follow-up method.

resultsOverall, 59% (1816) of invited women returned a urine sample for HPV testing. Response varied by screening history and index of area-level deprivation, but 39% of those who declined their last invited NHS screen responded favorably and took part in Catch-Up Screen. Telephone reminders yielded a 5% absolute increase in response compared to the text message arm (p = 0.007).

conclusionsAn at-home first-void urine sample is a viable method for a national catch-up HPV test and has the potential to address decreasing national coverage among older women being invited for their last screen.

Indexed as

Early Detection of CancerMass ScreeningPapillomavirus InfectionsUterine Cervical NeoplasmsAgedFeasibility StudiesFemaleHumansMiddle AgedUnited Kingdomcatch‐upcervical screeningfirst‐void urineHPVolder womenself‐sampling

Identifiers

PMID41397685
PMCPMC12884217

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.