Evidence map›Paper›PMID 41397966›Full record

ArticleNature communications2025

FL7 is an ancient ABA-independent inhibitor of PP2C-As regulating plant stress responses.

Tianli Li, Zitong Yang, Guojun Li, Jan de Vries, Yuke Li, Xianglan Li, Xu Lu, Xinyi Gu, Zhaojie Chen, Yang Zhao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tianli Li *State Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.ORCID http://orcid.org/0000-0001-5517-6239
Zitong Yang *State Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.ORCID http://orcid.org/0009-0008-5514-8308
Guojun LiCAS Center for Excellence in Molecular Plant Sciences, The Chinese Academy of Sciences, Shanghai, China.
Jan de VriesDepartment of Applied Bioinformatics, University of Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0003-3507-5195
Yuke LiState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.
Xianglan LiState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.
Xu LuState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.
Xinyi GuState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.
Zhaojie ChenGuangxi Key Laboratory of Agric-Environment and Agric-Products Safety, College of Agriculture, Guangxi University, Nanning, Guangxi, China.
Yang ZhaoCAS Center for Excellence in Molecular Plant Sciences, The Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-0302-3470
Daolong DouState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China.ORCID http://orcid.org/0000-0001-5226-6642
Danyu ShenState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China. shendanyu@njau.edu.cn.ORCID http://orcid.org/0000-0002-2973-0010
Gan AiState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing, China. ganai@njau.edu.cn.ORCID http://orcid.org/0000-0002-2094-5461

Funding

Agriculture Research System of China (China's Agricultural Research System) CARS-21National Natural Science Foundation of China (National Science Foundation of China) 32230089National Natural Science Foundation of China (National Science Foundation of China) 32372493Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20230984
6 · The paper itself

Abstract

Clade A protein phosphatase 2Cs (PP2C-As) play crucial roles in plant stress responses. Although the ABA receptors PYLs inhibit PP2C-As in an ABA-dependent manner, other modulators of these phosphatases remain largely unknown. Here, we identify the FORKED-LIKE 7 (FL7) protein as a broad PP2C-A interactor that effectively suppresses PP2C activity through an ABA-independent, noncompetitive mechanism. By inhibiting PP2C-A activity, FL7 positively regulates osmotic tolerance and plant immunity in an ABA-independent manner. The N-terminal auxin canalisation (AC) domain of FL7 is required for its PP2C-As inhibitory activity. Further evolutionary analyses reveal that FL7 homologues containing an AC domain belong to an ancient family that emerged in a common ancestor of Klebsormidiophyceae algae and land plants. Genetic analyses indicate that algal FL7 homologues have a conserved function as PP2C-A inhibitors. Our study reveals an ABA-independent layer of PP2C-A modulation that regulates biotic and abiotic stress responses, which is likely conserved across a billion years of streptophyte evolution and predated the PYL-ABA regulation established in the common ancestor of land plants.

Indexed as

Abscisic AcidArabidopsisArabidopsis ProteinsPhosphoprotein PhosphatasesPlant ProteinsProtein Phosphatase 2CStress, PhysiologicalGene Expression Regulation, PlantIndoleacetic AcidsPhylogenyPlant ImmunityAbscisic AcidArabidopsis ProteinsIndoleacetic AcidsPhosphoprotein PhosphatasesPlant ProteinsProtein Phosphatase 2C

Identifiers

PMID41397966
PMCPMC12705697

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.