Evidence map›Paper›PMID 41397974›Full record

ArticleNature communications2025

A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry.

Fengfeng Zheng, Wenyong Yao, Wei He, Wan Zhang, Yufei Chen, Huahui Chen, Zhirui Zeng, Xiao-Lei Liu, Su Ding, Yanhong Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fengfeng Zheng *Shenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China. zhengff@sustech.edu.cn.ORCID http://orcid.org/0000-0002-8507-162X
Wenyong Yao *Shenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Wei He *Shenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0003-3997-4526
Wan ZhangShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Yufei ChenShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Huahui ChenShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Zhirui ZengShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-9905-8955
Xiao-Lei LiuSchool of Geosciences, University of Oklahoma, Norman, OK, USA.ORCID http://orcid.org/0000-0002-0218-3029
Su DingDepartment of Marine Microbiology and Biogeochemistry, NIOZ Royal Institute for Sea Research, Texel, The Netherlands.ORCID http://orcid.org/0000-0001-6213-3982
Yanhong ZhengState Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi'an, China.
Linan HuangSchool of Life Sciences, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-4881-7920
Yuanqing ZhuShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Chuanlun ZhangShenzhen Key Laboratory of Marine Archaea Geo-Omics, Department of Ocean Science and Engineering, Southern University of Science and Technology, Shenzhen, China. zhangcl@sustech.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32393974National Natural Science Foundation of China (National Science Foundation of China) 42372354
6 · The paper itself

Abstract

Archaeal membrane lipids are markedly distinct from those in bacteria and eukaryotes, serving as biomarkers for unraveling their ecological and biogeochemical roles. Recent advancements in high-resolution mass spectrometry-based lipidomic research facilitate detailed cellular-level characterizations of lipid compounds. However, the lack of a comprehensive and dedicated database severely limits large-scale, high-throughput investigations of archaeal lipids. We present ArchLips, a comprehensive database containing 219,348 in silico molecular structures and tandem mass spectra of 199,248 corresponding archaeal lipid compounds. ArchLips enables the automatic and accurate annotation of archaeal lipid compounds characterized by high-resolution mass spectrometry from both pure cultures and environmental samples, serving as a transformative tool for enhancing our understanding of archaeal diversity and its ecological and evolutionary significance within global ecosystems.

Indexed as

ArchaeaDatabases, FactualLipidomicsLipidsMass SpectrometryMembrane LipidsTandem Mass SpectrometryLipidsMembrane Lipids

Identifiers

PMID41397974
PMCPMC12808674

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.