Evidence map›Paper›PMID 41398146›Full record

ArticleNature communications2025

Comprehensive discovery of m

Gihyeon Kang, Hyeonseo Hwang, Hyeonseong Jeon, Heejin Choi, Hee Ryung Chang, Nagyeong Yeo, Junehee Park, Narae Son, Eunkyeong Jeon, Jungmin Lim and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Comprehensive discovery of mNature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gihyeon Kang *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Hyeonseo Hwang *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-8213-5977
Hyeonseong Jeon *Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Heejin Choi *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Hee Ryung Chang *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Nagyeong Yeo *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0003-9759-8001
Junehee ParkSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Narae SonSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Eunkyeong JeonSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Jungmin LimSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Jaeung YunSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Wook ChoiGenome4me, Inc., Seoul, Republic of Korea.
Jae-Yoon JoSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Jong-Seo KimSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-8909-8440
Sangho ParkGenome4me, Inc., Seoul, Republic of Korea.
Yoon Ki KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0003-1303-072X
Daehyun BaekSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea. baek@snu.ac.kr.

Funding

Korea Health Industry Development Institute (KHIDI) RS-2025-25422732Ministry of Health, Welfare and Family Affairs | Korea National Institute of Health (KNIH) 2022-ER1605-00National Research Foundation of Korea (NRF) RS-2020-NR049538National Research Foundation of Korea (NRF) RS-2022-NR067483National Research Foundation of Korea (NRF) RS-2025-02273009
6 · The paper itself

Abstract

RNA modifications (RMs) are critical for diverse biological processes, but the lack of accurate, quantitative detection methods has limited their study. A large-scale and high-quality training dataset is an essential component for accurate deep learning, but such dataset has been absent for RM detection, resulting in low accuracies. We developed DeepRM (Deep learning for RNA Modification), a sophisticated deep learning framework powered by Nanopore sequencing. DeepRM dataset is a massive-scale, three orders of magnitude larger than the comparable previous ones, and unprecedentedly high-quality dataset that closely mirrors endogenous transcript environments. Accordingly, DeepRM detects RM sites and measures their modification stoichiometries with a near-perfect accuracy. Using DeepRM, we constructed a comprehensive, human m

Indexed as

AdenosineRNARNA Processing, Post-TranscriptionalTranscriptomeDeep LearningHumansNanopore SequencingRNA, MessengerSequence Analysis, RNASingle Molecule ImagingAdenosineN-methyladenosineRNARNA, Messenger

Identifiers

PMID41398146
PMCPMC12816753

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.