Evidence map›Paper›PMID 41398258›Full record

Observational studyBMC women's health2025

Diagnostic discrepancies and clinical value of second medical opinions (SMO) for endometriosis: a nationwide study analysis.

Constance Durant des Aulnois, Elie Zerbib, Hélène Barberousse, Pierre Panel, Isabelle Holway, Corinne Balleyguier, Alexandre Bellucci, Téodor Grand, Jonathan Zerbib, Corinne Bordonné and 19 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Constance Durant des AulnoisDepartment of Gynecology-Obstetrics and Reproductive Medicine, Tenon Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France, 75020.
Elie ZerbibDepartment of Gynecology-Obstetrics and Reproductive Medicine, Tenon Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France, 75020.
Hélène BarberousseScientific Department, Deuxième Avis, Paris, 75015, France.
Pierre PanelDepartment of Gynecology and Obstetrics, Centre Hospitalier de Versailles, Le Chesnay, France.
Isabelle HolwayDepartment of Surgery and Gynecology, American Hospital of Paris, 55 Bd du Château, Neuilly-sur-Seine, 92200, France.
Corinne BalleyguierImaging Department, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94805, France.
Alexandre BellucciHôpital Européen Georges Pompidou AP-HP, 20 rue Leblanc, Paris, 75015, France.
Téodor GrandHôpital Européen Georges Pompidou AP-HP, 20 rue Leblanc, Paris, 75015, France.
Jonathan ZerbibHôpital Européen Georges Pompidou AP-HP, 20 rue Leblanc, Paris, 75015, France.
Corinne BordonnéImagerie Médicale Paris Centre IMPC, 80 Rue Montmartre, Paris, 75002, France.
Thibault CarteretIMAGIR - Centre d'Imagerie Meriadeck-Lecocq, 126 rue Lecocq, Bordeaux, 33000, France.
Anne-Coline Monseau-ThiburceIMAGIR - Centre d'Imagerie Meriadeck-Lecocq, 126 rue Lecocq, Bordeaux, 33000, France.
Sophie GehinCentre Hospitalier Chalon sur Saône William Morey, 4 Rue Capitaine Drillien, Chalon-sur-Saône, 71321, France.
Erick PetitHôpital Paris Saint-Joseph, Centre de l'endométriose, 185 Rue Raymond Losserand, Paris, 75014, France.
Marie CeccarelliHôpital Paris Saint-Joseph, Centre de l'endométriose, 185 Rue Raymond Losserand, Paris, 75014, France.
Anne-Marie TardivelHôpital Privé Wallerstein, Imagerie Médicale Nord Bassin, 14 Bd Javal, Arès, 33740, France.
Shahed BorojeniClinique Saint Jean de Dieu, 2 rue Rousselet, Paris, 75007, France.
Sarah EskenaziInstitut de la Femme et de l'Endométriose, 5 Allée Arnaud Belatrame, 75003, Paris, France.
Jean-Philippe EstradeHôpital Privé de Provence, 235 All. Nicolas de Staël, Aix-en-Provence, 13080, France.
François GuillibertHôpital Privé de Provence, 235 All. Nicolas de Staël, Aix-en-Provence, 13080, France.
Ludovic FriederichDepartment of Surgery and Gynecology, American Hospital of Paris, 55 Bd du Château, Neuilly-sur-Seine, 92200, France.
Elise FuretClinique Turin, 5 Rue de Turin, Paris, 75008, France.
Vincent LavoueDepartment of Gynecology, CHU de Rennes, 2 Rue Henri le Guilloux, Rennes, 35000, France.
Benjamin MerlotClinique Tivoli, 91 rue Riviere, Bordeaux, 33000, France.
Paul PirteaHôpital Foch, 40 Rue Worth, Suresnes, 92150, France.
Sophie WarembourgDepartment of Gynecology-Obstetrics, Hospices Civils de Lyon, Croix Rousse Hospital, 103 Grand Rue de la Croix-Rousse, Lyon, 69004, France.
Hélène CreuxPolyclinique Saint Roch, 560 Av. du Colonel André Pavelet dit Villars, Montpellier, 34000, France.
Yohann DabiDepartment of Gynecology-Obstetrics and Reproductive Medicine, Tenon Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France, 75020.
Sofiane BendifallahDepartment of Surgery and Gynecology, American Hospital of Paris, 55 Bd du Château, Neuilly-sur-Seine, 92200, France. sofiane.bendifallah@yahoo.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to evaluate the second medical opinions (SMOs) clinical value for endometriosis diagnostic strategy and patient profiles, using nationwide data from a specialized French physician network dedicated to SMOs and endometriosis management. METHODS & MATERIALS: We conducted an observational cohort study including patients from France who submitted a request for an SMO through a dedicated platform ( https://www.deuxiemeavis.fr/ ) between January 1st, 2020, and March 31st, 2024. Patients completed predefined questionnaires and subsequently received a written report following the expert SMO.

resultsA total of 3,061 patients requested a SMO for endometriosis. Most patients (61.1%) declared experiencing chronic painful symptoms a negative impact on daily life, corresponding to an Eastern Cooperative Oncology Group (ECOG) score ≥ 1. Dysmenorrhea was reported by 50.7% of patients, and 69.4% reported interruption of intercourse due to pain. Among the 2,987 patients with a complete medical record, the SMO modified the diagnosis in 51.1% of cases. After SMO, experts were unable to establish a conclusion in only 5.0% of cases, compared to 24.7% after the first medical opinion. For patients finally diagnosed with endometriosis, the SMO provided a diagnosis at a mean of 3.8 ± 1.5 years after symptom onset.

conclusionSeeking a SMO with access to medical experts can be essential for patients dealing with painful symptoms unsuccessfully treated, or other problems such as endometriosis diagnosis.

Indexed as

Diagnostic ErrorsEndometriosisReferral and ConsultationAdultCohort StudiesDysmenorrheaFemaleFranceHumansMiddle AgedSurveys and QuestionnairesEndometriosisEndometriosis diagnosisSecond medical opinion

Identifiers

PMID41398258
PMCPMC12706957

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.