Evidence map›Paper›PMID 41398377›Full record

ReviewNPJ digital medicine2025

Crossing borders securely: synthetic data and federated networks for privacy-preserving access to real-world data and emerging use cases.

Echo H Wang, Puja Myles, Randi Foraker, Sengwee Toh, Lucy Mosquera, Khaled El Emam, Mehmet Burcu

Abstract readReview
In one paragraph

Review in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Echo H WangMerck & Co., Inc., Rahway, NJ, USA.
Puja MylesMedicines and Healthcare products Regulatory Agency (MHRA), 10 South Colonnade, Canary Wharf, London, UK.
Randi ForakerUniversity of Missouri School of Medicine, Columbia, MO, USA.
Sengwee TohHarvard Medical School, Boston, MA, USA.
Lucy MosqueraAetion, a Datavant Company, Ottawa, Canada.
Khaled El EmamUniversity of Ottawa, Ottawa, Canada.
Mehmet BurcuMerck & Co., Inc., Rahway, NJ, USA. mehmet.burcu@merck.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The demand for demographically and geographically diverse, high-quality, fit-for-purpose real-world data has been increasing to support regulatory and other healthcare decision making. Accessing and sharing healthcare data across sites, regions, and countries while ensuring data privacy has been a long-standing challenge. We discuss synthetic data and federated data networks as examples of emerging privacy-preserving technologies and provide real-life use cases from government, industry, and academia with their opportunities and challenges.

Identifiers

PMID41398377
PMCPMC12705744

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.