Evidence map›Paper›PMID 41398509›Full record

SynthesisJournal of the Association for Research in Otolaryngology : JARO2026

Investigation of Vestibular Dysfunction Requires Renewed Research Enthusiasm.

Evan M Ratzan, William Davis, Jacob R Brodsky

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the Association for Research in Otolaryngology : JARO, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Evan M RatzanDepartment of Otolaryngology, Boston Children's Hospital and Harvard Medical School, Boston, USA. Evan.Ratzan@childrens.harvard.edu.ORCID http://orcid.org/0009-0000-5018-4598
William DavisDepartment of Otolaryngology, Boston Children's Hospital and Harvard Medical School, Boston, USA.
Jacob R BrodskyDepartment of Otolaryngology, Boston Children's Hospital and Harvard Medical School, Boston, USA.

Funding

TMC gene function in sensory hair cellsR01DC013521 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI JEFFREY R HOLT · 2013 to 2026
$6.0M
Defining the role of MET components in vestibular hair cell maturation and gene therapy responsivenessK99DC022343 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI Evan Ratzan · 2025 to 2026
$265k
NIDCD NIH HHS K99 DC022343NIDCD NIH HHS K99 DC02234301NIDCD NIH HHS R01 DC013521
6 · The paper itself

Abstract

Inner ear research has experienced exponential growth for the last fifty years spurring the creation of novel scientific approaches and clinical intervention strategies. Here we utilize data mining of publicly available records (PubMed, NIHReporter, and ClinicalTrials.gov) to assess the rate of inner ear research output quantitatively. We combined this approach with systematic review of published literature to understand the prevalence and monetary costs of seeking treatment for hearing and balance. The data show that the expansive growth period of inner ear research presents a new challenge for scientists and clinicians as auditory research output metrics have begun to significantly outpace vestibular research. There are unique challenges associated with diagnosing and treating patients with vestibular dysfunction that may explain some of the discrepancies in research output. A renewed enthusiasm to investigate the vestibular system may help facilitate broader understanding of the inner ear and has potential to produce improved scientific methods and clinical interventions for patients.

Indexed as

Biomedical ResearchVestibular DiseasesHumansAuditoryBalanceCochleaHearingInner earUtricleVestibular

Identifiers

PMID41398509
PMCPMC12949205

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.