ArticleBMC infectious diseases2025
Association between serum uric acid to albumin ratio and all-cause mortality in critically ill patients with sepsis: a retrospective study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Prognostic Role of Uric Acid-to-Albumin Ratio in Patients with Metastatic Breast Cancer Treated with CDK4/6 Inhibitors.Journal of clinical medicine · 2026Article
- Independent factors associated with renal impairment in preeclampsia and its association with maternal and neonatal adverse outcomes.Frontiers in medicine · 2026Article
- Hematologic and metabolic indices for predicting 28-day mortality in sepsis patients: a retrospective intensive care cohort study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe serum uric acid to albumin ratio (UAR) is a recently recognized composite inflammatory biomarker that has not received sufficient attention in relation to sepsis. This study aimed to investigate the association between UAR and the risk of all-cause mortality in critically ill patients with sepsis.
methodsWe conducted an analysis using a retrospective database of sepsis patients who were admitted to the Affiliated Hospital of Jiangsu University between January 2015 and November 2023. The patients were divided into four groups based on UAR quartiles. The primary outcome was in-hospital all-cause mortality. The Kaplan-Meier curve and log-rank tests were used to evaluate all-cause mortality among the four groups. Cox proportional hazards regression analysis and restricted cubic splines were performed to examine the association between UAR and clinical outcomes in patients with sepsis. Subgroup analyses were conducted to evaluate the impact of other variables on the relationship between UAR and all-cause mortality.
resultsA total of 1123 patients (63.0% males) were included in this study. The in-hospital and intensive care unit (ICU) mortality rates were 33.9% and 31.7%, respectively. There was a significant association between higher UAR levels and an increased cumulative incidence of 30-/60-day mortality (log-rank test, P < 0.001). Cox proportional hazards regression analysis demonstrated that the UAR was independently associated with a higher risk of in-hospital mortality [per SD increase in the UAR: hazard ratio (HR) (95%CI): 1.186 (1.067–1.319); P = 0.002] and ICU mortality [per SD increase in the UAR: HR (95%CI): 1.190 (1.068–1.327); P = 0.002]. Restricted cubic spline regression analysis illustrated a linear relationship between UAR and the risks of in-hospital and ICU mortality.
conclusionsElevated UAR levels were strongly associated with all-cause mortality in critically ill patients with sepsis, suggesting their potential as predictors of poor outcomes. However, further studies are needed to validate our findings and investigate the underlying causal factors that could contribute to sepsis prevention and treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.