Evidence map›Paper›PMID 41398595›Full record

ArticleItalian journal of pediatrics2025

Predictive value of blood composite ratios for Kawasaki disease and coronary artery lesions in febrile children.

Shuhuan Li, Senhong Guan, Lanyuan Liu, Sheng Chen, Zhaohan Yan, Yunying Zeng, Fengshan Ouyang, Jiankai Zhong

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Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shuhuan Li *Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Senhong Guan *Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Lanyuan Liu *Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Sheng ChenDepartment of Cardiology, Zhujiang Hospital, Sanshui Hospital, Southern Medical University, Foshan, Guangdong, 528100, China.
Zhaohan YanDepartment of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Yunying ZengDepartment of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Fengshan OuyangDepartment of Rehabilitation Medicine, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China.
Jiankai ZhongDepartment of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, 528308, China. doctor-zh@smu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515140125Key Specialist Department Training Project of Foshan, Guangdong Province of China Fspy 3-2015034Science and Technology Innovation Project of Foshan, Guangdong FS0AA-KJ218-1301-0006; FS0AA-KJ218-1301-0010Science and Technology Project of Foshan 2220001003865Scientific Research Start Plan of Shunde Hospital, Southern Medical University SRSP2019004the Medical Science and Technology Research Foundation of Guangdong Province of China A2023151
6 · The paper itself

Abstract

backgroundKawasaki disease (KD) is a systemic vasculitis in children, with coronary artery lesions (CALs) presenting as severe complications. Early diagnosis is of paramount importance; however, current biomarkers lack both simplicity and reliability. This study assessed the predictive value of blood composite ratios (BCRs) for KD and CAL.

methodsIn this retrospective study, we analyzed data from 153 pediatric patients with febrile illness from 2016 to 2023. BCRs, including the neutrophil-to-lymphocyte ratio (NLR), the eosinophil-to-lymphocyte ratio (ELR), the eosinophil-to-monocyte ratio (EMR), and the eosinophil-to-basophil ratio (EBR), were calculated from admission laboratory data. The relationships between BCRs and the incidence of KD and CAL were evaluated using statistical and regression analyses.

resultsPatients with KD presented markedly elevated NLRs, ELRs, EMRs, and EBRs in comparison with those in the febrile control group. The NLR and ELR were found to be significantly associated with the incidence of KD and CAL, with optimal cutoff values of 0.632 and 0.01, respectively. The combined use of BCR indices resulted in increased predictive efficacy for the incidence of KD.

conclusionsBCRs, particularly the NLR and ELR, are valuable for the early identification of high-risk KD patients and CAL damage. These ratios have the potential to enhance clinical management and optimize patient care, although validation in prospective studies is needed.

Indexed as

Coronary Artery DiseaseFeverMucocutaneous Lymph Node SyndromeBiomarkersChildChild, PreschoolFemaleHumansIncidenceInfantLeukocyte CountMalePredictive Value of TestsRetrospective StudiesBiomarkersBlood composite ratiosCoronary artery lesionsKawasaki diseasePediatric cardiologyPredictive value

Identifiers

PMID41398595
PMCPMC12706987

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.