Trial reportMedicine2025
Adoption of plasma D-dimer testing, color Doppler ultrasound, and enoxaparin sodium in predicting and preventing lower extremity deep vein thrombosis in high-risk parturients undergoing cesarean section.
Trial report in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to explore the clinical value of plasma D-dimer (D-D) testing, color Doppler ultrasound, and enoxaparin sodium in predicting and preventing lower extremity deep vein thrombosis (DVT) in high-risk parturients undergoing cesarean section. Eighty-six high-risk parturients were randomly rolled into an observation (Obs) group and a control (Ctrl) group (86 cases each). Ctrl group received routine preventive measures, while Obs group received additional enoxaparin sodium prophylaxis on the basis of the routine preventive measures. Plasma D-D levels were monitored, and color Doppler ultrasound was performed to assess lower extremity venous blood flow velocity. The incidence of venous thrombosis and coagulation function indicators before and after treatment were compared between the 2 groups. The incidence of venous thrombosis in Obs group was inferior to that in Ctrl group (P < .05). After treatment, the activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-D, platelet count (PLT), plasma viscosity (PV), whole blood high shear viscosity (HBV), and whole blood low shear viscosity (LBV) in Obs group were inferior to before treatment (P < .05), while the erythrocyte deformability index (EDI) was superior to before treatment (P < .05). Additionally, the levels of D-D, FIB, PT, APTT, PLT, PV, HBV, and LBV in Obs group were inferior to those in Ctrl group (P < .05), but the EDI was superior to that in Ctrl group (P < .05). After treatment, the blood flow velocities of the femoral deep vein, popliteal vein, and posterior tibial vein in both the observation and Ctrl groups greatly increased versus before treatment (P < .05), with Obs group showing higher velocities than Ctrl group (P < .05). The incidence of postoperative complications in Obs group was also markedly inferior to that in Ctrl group (P < .05). Postpartum bleeding differed slightly in Obs group (P > .05). The visual analogue scale score of Obs group was notably superior to that of Ctrl group (P < .05). Enoxaparin sodium effectively improved postpartum coagulation function and reduced the incidence of lower extremity DVT in high-risk parturients undergoing cesarean section. Plasma D-D levels and color Doppler ultrasound are screening methodologies for lower extremity DVT, which can improve the success rate of early diagnosis and treatment.
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