Observational studyMedicine2025
Association between albumin-related inflammatory biomarkers and breast cancer risk: A secondary analysis of NHANES 1998-2018.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Preoperative lymphocyte-albumin-monocyte index as an inflammation- and nutrition-based predictor of overall survival in triple-negative breast cancer: A retrospective cohort study.Oncology letters · 2026Article
- Neutrophil Percentage-to-Albumin Ratio as a Prognostic and Predictive Biomarker in Non-Metastatic Breast Cancer Treated with Neoadjuvant Chemotherapy: Findings from a Retrospective Cohort.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer (BC) is a leading cause of cancer-related mortality among women globally. Inflammation and nutritional status play critical roles in BC development and progression. Albumin-related inflammatory biomarkers, which reflect both inflammatory and nutritional status, have been increasingly recognized as important indicators in cancer initiation and progression. However, their role in BC risk remains largely unexplored. This study aimed to investigate the association between albumin-related inflammatory biomarkers and BC risk. Female' data within the age range of 20 to 80 from the National Health and Nutrition Examination Survey (1998-2018) were extracted. Weighted logistic regression and restricted cubic spline regression analyses were performed to explore the association between 4 albumin-related inflammatory biomarkers (neutrophil percentage-to-albumin ratio [NPAR], lymphocyte-to-albumin ratio [LYAR], leukocyte-to-albumin ratio, and platelet-to-albumin ratio) and BC risk. Subgroup analyses were conducted to assess the influence of covariates, and sensitivity analyses were performed to ensure the robustness of the findings. Among 14,211 female participants, 357 were diagnosed with BC. A linear positive relationship was observed between NPAR and BC (odds ratio = 1.08; 95% confidence interval: 1.02-1.14; P = .008), with participants in the highest quartile of NPAR exhibiting a significantly increased risk compared to those in the lowest quartile (odds ratio = 1.60; 95% confidence interval: 1.05-2.44; P for trend = 0.016). In contrast, LYAR demonstrated a nonlinear protective association with BC (P for overall < .001; P for nonlinear < .001), with higher levels linked to reduced risk. Leukocyte-to-albumin ratio and platelet-to-albumin ratio were not significantly associated with BC. Findings from subgroup and sensitivity analyses were consistent with the main findings. Our study highlighted the potential role of NPAR and LYAR in BC risk assessment. They may serve as available and cost-effective tools for identifying high-risk individuals and facilitating early intervention. Further studies are warranted to evaluate the potential of albumin-related inflammatory biomarkers in the early diagnosis of BC.
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