ArticleCardiovascular diabetology. Endocrinology reports2025
Impact of medication therapy management intervention on medication adherence among adult patients comorbid with diabetes mellitus and hypertension at outpatient clinics in Southwest Ethiopia: a cluster randomized controlled trial.
Article in Cardiovascular diabetology. Endocrinology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06112925 (Impact of Medication Therapy Management Intervention on Treatment Outcomes and Medication Adherence Among Adult Patients Comorbid With Diabetes Mellitus and Hypertension at Outpatient Clinics in Southwest Ethiopia), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Impact of Medication Therapy Management Intervention on Treatment Outcomes and Medication Adherence Among Adult Patients Comorbid With Diabetes Mellitus and Hypertension at Outpatient Clinics in Southwest Ethiopia: A Cluster Randomized Controlled Trial
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Artificial Intelligence in Cardiovascular Medicine: Focus on Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Pooled it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with diabetes and hypertension require long-term medication, which may increase the chance of non-adherence to medications. Medication therapy management has been shown to positively impact medication adherence. This study aimed to assess the impact of medication therapy management on medication adherence among patients comorbid with diabetes mellitus and hypertension.
methodsA cluster randomized controlled trial was conducted at outpatient clinics from January 03 to July 18, 2022. The hospital was randomly assigned to either the intervention or control group. The patients attending hospitals assigned to the interventional group received medication therapy management services in addition to usual care. A systematic random sampling technique was used to select the study participants from each hospital. Medication adherence was assessed using the Adherence in Chronic Diseases Scale. SPSS version 24.0 was used for data analysis. The independent sample t-test and chi-square test were used to compare the variables.
resultOf 402 eligible patients, 201 were randomly assigned to the medication therapy management intervention group and 201 patients were randomized to the control group. No significant differences were observed in the baseline characteristics of the patients. The adherence rate in the intervention group increased by 50%, whereas it remained fairly constant in the control group, and the difference was statistically significant (p < 0.001).
conclusionThe current study showed that medication therapy management intervention improved the patients’ medication adherence. Hospitals should strengthen and integrate clinical pharmacy services into their healthcare system.
trial registrationClinicalTrials.Gov NCT06112925.
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