ArticleRenal failure2025
Platelet-to-high-density lipoprotein cholesterol ratio as a potential mediator in the obesity-chronic kidney disease association among hypertensive patients.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigated the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and chronic kidney disease (CKD) in a hypertensive population, exploring its mediating role in the obesity-CKD association. Using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2018 on 10,467 hypertensive adults, we observed a complex association. Overall, PHR was positively correlated with CKD (odds ratio [OR] = 1.08, 95% CI: 1.05-1.14). However, the relationship was nonlinear and U-shaped, with an inflection point at a PHR Z-score of -0.32 (PHR = 166). Below this point, the association was negative (OR = 0.78, 95% CI: 0.65-0.91), whereas above it, the association was strongly positive (OR = 1.24, 95% CI: 1.15-1.36), particularly among individuals with obesity (BMI ≥ 30 kg/m
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