Evidence map›Paper›PMID 41399191›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.

Sean J Colloby, Anita Nitchingham, Sarah Richardson, Rachel A Lawson, John T O'Brien, Eva A Wegner, Robert Welschinger, Gideon A Caplan, John-Paul Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sean J CollobyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Anita NitchinghamDepartment of Geriatric Medicine, Prince of Wales Hospital, Sydney, Australia.
Sarah RichardsonAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Rachel A LawsonTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
John T O'BrienDepartment of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Eva A WegnerNuclear Medicine Department, Prince of Wales Hospital, Sydney, Australia.
Robert WelschingerDepartment of Geriatric Medicine, Prince of Wales Hospital, Sydney, Australia.
Gideon A CaplanDepartment of Geriatric Medicine, Prince of Wales Hospital, Sydney, Australia.
John-Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Funding

NIHR Newcastle Biomedical Research Centre
6 · The paper itself

Abstract

backgroundDelirium is an acute neuropsychiatric condition linked to increased dementia risk, yet its mechanisms remain unclear. Previous studies reported cerebral hypometabolism. Spatial covariance of

methodsSeventy participants were included (30 Con

resultsThe DP distinguished Con DISCUSSION: Delirium exhibited a metabolic profile of network dysfunction that may be modifiable and clinically responsive. HIGHLIGHTS: Derivation of a DP, primarily attributable to delirium itself, rather than acute illness or dementia. The DP revealed metabolic dysfunction spanning large-scale networks, consistent with the proposed model of delirium as global brain failure. DP expression was elevated in delirium, both with and without dementia, compared to healthy and acutely unwell controls. In participants with follow-up, clinical recovery was paralleled by a reduction in DP expression. The delirium pattern reflected clinically responsive and modifiable network dysfunction.

Indexed as

BrainDeliriumDementiaAgedAged, 80 and overFemaleFluorodeoxyglucose F18HumansMalePositron-Emission TomographyFluorodeoxyglucose F1818F‐fluorodeoxyglucose positron emission tomographycerebral glucose metabolismdeliriumdementianeuroimagingspatial covariance

Identifiers

PMID41399191
PMCPMC12706124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.