Evidence map›Paper›PMID 41399266›Full record

ArticleJournal of Korean medical science2025

Efficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study.

Sang Gyu Lee, Joo Hee Lee, Yujin Baek, Jaeryang Chu, Kyung Hwan Kim, Seoyoon Ham, Chang Hun Shin, Young In Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbiome-Derived Indole-3-Lactic Acid AttenuatesInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sang Gyu Lee *Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6237-9031
Joo Hee Lee *Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7379-1195
Yujin BaekDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0009-0004-3463-6661
Jaeryang ChuMicrobiome Research Laboratory, Chong Kun Dang Bio Research Institute, Ansan, Korea.ORCID https://orcid.org/0000-0002-5925-7324
Kyung Hwan KimMicrobiome Research Laboratory, Chong Kun Dang Bio Research Institute, Ansan, Korea.ORCID https://orcid.org/0000-0002-2294-5094
Seoyoon HamDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0009-0002-5569-9579
Chang Hun ShinChong Kun Dang Bio Research Institute, Ansan, Korea.ORCID https://orcid.org/0000-0002-7598-7124
Young In LeeDepartment of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6831-7379

Funding

Ministry of Trade, Industry and Energy 20024192
6 · The paper itself

Abstract

backgroundThe skin microbiome plays a crucial role in defending against pathogens and modulating immunity, and its dysregulation is linked to various skin conditions, including acne.

methodsIn this study, four previously identified strains-

results

conclusionThese results provide compelling evidence of the efficacy and safety of human skin microbiome-derived strains as potential topical treatments for acne. By targeting both microbial colonization and inflammatory pathways, these strains offer a promising avenue for the development of novel acne therapeutics.

Indexed as

Acne VulgarisMicrobiotaSkinAnimalsCyclooxygenase 2CytokinesDisease Models, AnimalFemaleHumansKeratinocytesMaleMicePropionibacterium acnesSkin MicrobiomeStaphylococcus epidermidisCyclooxygenase 2CytokinesAcne VulgarisCutibacterium acnesInflammationMicrobiome

Identifiers

PMID41399266
PMCPMC12708972

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.