Evidence map›Paper›PMID 41399345›Full record

ArticleGastro hep advances2025

Identification of Genetic Risk Factors Associated With Herbal and Dietary Supplement-Induced Acute Liver Failure Using Whole Exome Sequencing Analysis.

Tsung-Jen Liao, Menghang Xia, Dingyin Tao, Yanyan Qu, Baitang Ning, Jody A Rule, William M Lee, Ruili Huang, Jorge Rakela, Minjun Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tsung-Jen LiaoDivision of Bioinformatics and Statistics, The FDA's National Center for Toxicological Research, Jefferson, Arkansas.
Menghang XiaDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
Dingyin TaoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
Yanyan QuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
Baitang NingDivision of Bioinformatics and Statistics, The FDA's National Center for Toxicological Research, Jefferson, Arkansas.
Jody A RuleDivision of Gastroenterology and Hepatology, University of Texas Southwestern, Dallas, Texas.
William M LeeDivision of Gastroenterology and Hepatology, University of Texas Southwestern, Dallas, Texas.
Ruili HuangDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.
Jorge RakelaDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona.
Minjun ChenDivision of Bioinformatics and Statistics, The FDA's National Center for Toxicological Research, Jefferson, Arkansas.

Funding

A Multi-Center Study of Acute Liver Failure in AdultsU01DK058369 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DURKALSKI, VALERIE L, FONTANA, ROBERT J · 2005 to 2019
$27.4M
A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURER01DK058369 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI LEE, WILLIAM M · 2000 to 2004
$4.2M
NIDDK NIH HHS R01 DK058369NIDDK NIH HHS U01 DK058369
6 · The paper itself

Abstract

Background and Aims: Herbal and dietary supplements (HDS) have been associated with liver injury and severe liver disease, including acute liver failure (ALF), collectively referred to as HDS-induced ALF (HDS-ALF). With the global increase in HDS usage, reports of HDS-ALF cases have also risen. Methods: Genetic analysis was conducted using whole exome sequencing data from 23 HDS-ALF cases, with population controls sourced from the 1000 Genomes Project. Single-nucleotide polymorphisms (SNPs) with chi-square test Results: Thirty-three SNPs were statistically significant ( Conclusion: This study identifies specific

Indexed as

Acute Liver FailureHerbal and Dietary SupplementHuman Leukocyte AntigenSex DifferenceWhole Exome Sequencing Analysis

Identifiers

PMID41399345
PMCPMC12702431

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.