Evidence map›Paper›PMID 41399352›Full record

ArticleMaterials today. Bio2025

Hyaluronic acid-based microgels loaded with fluticasone furoate for bleomycin-induced acute lung injury treatment.

Bo Liu, Michael Lush, Mollie R Nielsen, Brady J Sillman, Mena Asha Krishnan, Benson J Edagwa, Kristina Bailey, Bin Duan, Han-Jun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo LiuMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Michael LushDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mollie R NielsenMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Brady J SillmanDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mena Asha KrishnanMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Benson J EdagwaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Kristina BaileyDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Bin DuanMary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Han-Jun WangDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

NHLBI NIH HHS R01 HL152160NHLBI NIH HHS R21 HL170127
6 · The paper itself

Abstract

Acute lung injury (ALI) is a serious clinical condition characterized by intense inflammation and impaired pulmonary function. Excessive inflammatory response and reactive oxygen species (ROS) can cause pulmonary edema and subsequently acute respiratory distress syndrome (ARDS). In this study, we developed fluticasone furoate (FF)-loaded hyaluronic acid (HA)-amino phenylboronic acid (PBA)-epigallocatechin gallate (EGCG) based microgels (HPE@FF) as a novel therapeutic platform for ALI treatment. HPE@FF microgels were prepared by a facile one-pot method, integrating biocompatibility, intrinsic antioxidant and anti-inflammatory properties, and sustained FF delivery. The submicron-size microgels (0.1-1.6 μm) with 93 % encapsulation efficiency effectively reduced intracellular ROS in human lung fibroblast and mouse RAW264.7 cells

Indexed as

Acute lung injuryAnti-inflammatoryAntioxidantMicrogelPulmonary functions

Identifiers

PMID41399352
PMCPMC12702120

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.