ArticleInternational journal of medical sciences2026
Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer.
Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear.
methodsWe first compare the expression profiles of GPI-T subunits in HNC and then integrate multi-omics analyses to assess
resultsAmong the five subunits, PIGK was uniquely and consistently upregulated at both mRNA and protein levels in tumors. High PIGK expression correlates with aggressive clinicopathological features and poor survival across independent cohorts. Genomic analysis shows that
conclusionPIGK functions as a potential oncogenic driver in HNC with prognostic and therapeutic relevance. Its association with FAM20C, taxane response, and modulation of fibroblast activation provides insights into PIGK-mediated oncogenesis and may inform patient stratification strategies.
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