Evidence map›Paper›PMID 41399430›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Disparities and trends in pulmonary embolism mortality with and without obesity: a nationwide US analysis.

Aman Goyal, Humza Saeed, Samia Aziz Sulaiman, Muhammad Khubaib Arshad, Kevin Michael Alexander, Sripal Bangalore, Liana K Billings, Alfonso J Tafur, Manan Pareek, Gregory Piazza and 1 more

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aman GoyalDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Humza SaeedDepartment of Internal Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Samia Aziz SulaimanDepartment of Internal Medicine, University of Jordan, School of Medicine, Jordan.
Muhammad Khubaib ArshadDepartment of Internal Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Kevin Michael AlexanderDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Sripal BangaloreDivision of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA.
Liana K BillingsDepartment of Medicine, Endeavor Health/NorthShore, Skokie, Illinois, USA.
Alfonso J TafurDepartment of Vascular Medicine, Endeavor Health, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.
Manan PareekDepartment of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Gregory PiazzaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Arman QamarDivision of Interventional Cardiology and Vascular Medicine, NorthShore University Health System, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

Funding

Classification and Prognostication in Pulmonary Thromboembolism Using Computed Tomography Image AnalyticsR01HL164717 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Farbod Nicholas Rahaghi · 2022 to 2026
$3.6M
NHLBI NIH HHS R01 HL164717
6 · The paper itself

Abstract

Background: Obesity increases the risk of pulmonary embolism (PE) through multiple mechanisms. Objectives: This study examined mortality trends in patients with coexisting PE and obesity. Methods: We analyzed the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database for individuals aged 25 years and older who died between 1999 and 2020 from concurrent PE and obesity. Temporal trends and age-adjusted mortality rates (AAMRs) were assessed using Joinpoint regression software. Annual percent changes (APCs), average annual percentage change differences, and 95% CIs were calculated, with statistical significance set at Results: From 1999 to 2020, the AAMR for PE with obesity increased from 5.1 (95% CI, 4.7-5.4) to 13.9 (95% CI, 13.4-14.4) per 1,000,000. The AAMR rose significantly from 1999 to 2018 (APC, 3.45; 95% CI, 2.65-4.01; Conclusions: The analysis reveals a significant rise in mortality from concurrent PE and obesity, with higher rates observed in women, middle-aged adults, non-Hispanic Black individuals, and residents of nonmetropolitan areas. These findings highlight the need for targeted interventions in these high-risk groups.

Indexed as

disparityepidemiologymortalityobesitypulmonary embolismrisk factor

Identifiers

PMID41399430
PMCPMC12702333

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.