Evidence map›Paper›PMID 41399465›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Mitochondrial metabolic remodeling and multi-omics profiling identify plasma biomarkers of myocardial infarction.

Selvam Paramasivan, Mitchell C Lock, Roberto A Barrero, Paul C Mills, Janna L Morrison, Pawel Sadowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Selvam ParamasivanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Mitchell C LockClinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Roberto A BarreroeResearch, Research Infrastructure, Academic Division, Queensland University of Technology, Brisbane, QLD, Australia.
Paul C MillsSchool of Veterinary Science, The University of Queensland, Gatton, QLD, Australia.
Janna L MorrisonClinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Pawel SadowskiCentral Analytical Research Facility, Queensland University of Technology, Brisbane, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction is a hallmark of myocardial infarction (MI), yet the molecular mechanisms linking metabolic reprogramming in the ischemic myocardium to systemic biomarker signatures remain incompletely understood. In this study, we employed a data-independent acquisition mass spectrometry (SWATH-MS) strategy integrating multi-omics analysis with upstream regulatory network analysis to investigate mitochondrial energy pathway alterations in a preclinical ovine model of MI. Proteomic profiling of infarcted myocardium revealed a pronounced shift from oxidative phosphorylation to glycolysis, accompanied by coordinated suppression of mitochondrial fatty acid β-oxidation enzymes. This metabolic reprogramming was strongly associated with four upstream master regulators, most notably predicted inhibition and significant transcriptional downregulation of

Indexed as

MitochondriaMulti-omicsMyocardial infarctPlasma biomarkersProteomicsUpstream regulators

Identifiers

PMID41399465
PMCPMC12702414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.