ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025
Increased macrophage activity in coronary plaques in patients with acute coronary syndrome and familial hypercholesterolemia.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients with familial hypercholesterolemia (FH) experience acute coronary syndrome (ACS) at a younger age and have a higher risk of recurrent coronary events. The study aimed to elucidate the morphological characteristics of coronary plaques including the status of macrophages in patients with FH. Methods: This study included 259 patients with ACS who underwent optical coherence tomography (OCT) imaging of culprit plaques requiring percutaneous coronary intervention. The characteristics of culprit plaques and non-culprit plaques in the same coronary artery were compared between patients with and without FH. Results: A total of 23 patients (8.9 %) were clinically diagnosed with FH. In culprit plaques, the prevalence of both plaque with macrophages (69.6 % vs. 49.6 %, Conclusions: FH patients with ACS had more coronary plaques with macrophages, particularly in non-culprit segments, which may partly explain the increased risk of recurrent coronary events.
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