Evidence mapPaperPMID 41399786Full record

ArticleChinese herbal medicines2025

Unveiling bioactive components in

Yue Zhu, Yuting Ai, Jianfu Zhou, Xiaozhuan Jia, Shuying Liu, Bo Zhu, Yimin Qin, Jianping Jiang, Zhenzhong Yang

Abstract read
In one paragraph

Article in Chinese herbal medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue ZhuPharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yuting AiZhejiang Shiyuan Jinniu Biological Technology Co., Ltd., Hangzhou 310056, China.
Jianfu ZhouZhejiang Jingyuetang Pharmaceutical Co., Ltd., Shaoxing 312000, China.
Xiaozhuan JiaPharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Shuying LiuKey Laboratory of Seaweed Fertilizers, Ministry of Agriculture and Rural Affairs, Qingdao Bright Moon Seaweed Group Co. Ltd., Qingdao 266400, China.
Bo ZhuKey Laboratory of Seaweed Fertilizers, Ministry of Agriculture and Rural Affairs, Qingdao Bright Moon Seaweed Group Co. Ltd., Qingdao 266400, China.
Yimin QinKey Laboratory of Seaweed Fertilizers, Ministry of Agriculture and Rural Affairs, Qingdao Bright Moon Seaweed Group Co. Ltd., Qingdao 266400, China.
Jianping JiangHangzhou Lin'an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University, Hangzhou 311300, China.
Zhenzhong YangPharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Methods: SF from different origins and botanical parts were collected for integrated phytochemical analyses using ultra-high performance liquid chromatography-tandem quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS), mass spectral molecular networking and liquid chromatography-single quadrupole mass spectrometry (LC-MSD), etc., followed by the systematic chemical profile evaluation. Subsequently, the glycolipid metabolism regulation and anticoagulation of SF were examined. Furthermore, the overall information acquired was assembled using multivariate analysis and machine learning to discover bioactive components. Results: A total of 123 compounds in SF were identified with the assistance of mass spectral molecular networking. The variations in the content of amino acids, fucoidan, alginate, phlorotannin, alkaloids, terpenoids, etc. were observed in SF from different origins and botanical parts. SF possessed the hypolipidemic, hypoglycemic and anticoagulant effects, and SF from Dongtou, Wenzhou, Zhejiang, was outstanding among origins in both phytochemical and biological evaluations. A heterogeneous information ensemble approach was adopted to discover the bioactive components in SF, namely 3-indoleacrylic acid, phlorotannin and fucoidan. Conclusion: This study evaluated the phytochemical and biological properties of SF, revealed the bioactive components using heterogeneous information and provided a reference for the rational consumption and further development of SF.

Indexed as

anticoagulantchemical characteristic fusion analysischemometricsfucoidanmachine learningSargassum fusiforme (Harv.) Setch

Identifiers

PMID41399786
PMCPMC12702432

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.