Evidence map›Paper›PMID 41400249›Full record

ArticleeLife2025

The fate of pyruvate dictates cell growth by modulating cellular redox potential.

Ashish G Toshniwal, Geanette Lam, Alex J Bott, Ahmad A Cluntun, Rachel Skabelund, Hyuck-Jin Nam, Dona R Wisidagama, Carl S Thummel, Jared Rutter

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. NADThe EMBO journal · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ashish G ToshniwalDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0001-8957-7970
Geanette LamDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Alex J BottDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0003-2273-8922
Ahmad A CluntunDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0001-7612-8375
Rachel SkabelundDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Hyuck-Jin NamDepartment of Human Genetics, University of Utah, Salt Lake City, United States.
Dona R WisidagamaDepartment of Human Genetics, University of Utah, Salt Lake City, United States.
Carl S ThummelDepartment of Human Genetics, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0001-8112-4643
Jared RutterDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-2710-9765

Funding

Metabolic regulation of intestinal stem cell homeostasisR01CA228346 · NCI · UNIVERSITY OF UTAH · PI RUTTER, JARED P, THUMMEL, CARL S. · 2018 to 2022
$2.3M
Myc-induced expression of glutamine synthetaseK00CA212445 · NCI · UNIVERSITY OF UTAH · PI BOTT, ALEX · 2018 to 2021
$367k
Impact and regulation of lactate metabolism in the heartK99HL168312 · NHLBI · UNIVERSITY OF UTAH · PI CLUNTUN, AHMAD A · 2023 to 2024
$221k
American Heart Association 10.58275/aha.24post1201210.pc.gr.190781NCI NIH HHS K00 CA212445NCI NIH HHS R01 CA228346NHLBI NIH HHS K99 HL168312NIH HHS 1K99HL168312-01NIH HHS K00CA212445NIH HHS R01CA228346
6 · The paper itself

Abstract

Pyruvate occupies a central node in carbohydrate metabolism such that how it is produced and consumed can optimize a cell for energy production or biosynthetic capacity. This has been primarily studied in proliferating cells, but observations from the post-mitotic

Indexed as

Cell ProliferationHepatocytesPyruvic AcidAnimalsDrosophilaDrosophila melanogasterFat BodyGlycolysisHumansMitochondriaOxidation-ReductionSignal TransductionPyruvic Acidcell biologycell growthD. melanogastergeneticshepatocyteshumanpyruvate metabolismredox statetranslation

Identifiers

PMID41400249
PMCPMC12707817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.