ReviewBioscience reports2025
Myocardial stunning: mechanisms, molecular insights, and gaps in knowledge.
Review in Bioscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pharmacological strategies for myocardial protection in cardiac surgery: current science and the emerging role of multi-omics and artificial intelligence.Frontiers in cardiovascular medicine · 2026Review
- A Narrative Review of Risk Assessment Approaches for Implantable Defibrillator Therapy to Prevent Sudden Cardiac Death in Acute Myocardial Infarction.Cardiology research and practice · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial stunning, characterized by transient post-ischemic contractile dysfunction despite the restoration of coronary blood flow, has been a pivotal subject of cardiovascular research. Initially perceived as a consequence of irreversible myocardial damage and fibrosis, the concept evolved in the 1970s when studies revealed that reperfusion could salvage ischemic myocardium, leading to therapies like thrombolysis, percutaneous coronary intervention, and coronary artery bypass grafting. The phenomenon of myocardial stunning was first detailed by Heyndrickx et al. and later termed by Braunwald and Kloner, challenging previous views by demonstrating that reperfusion can cause temporary yet reversible dysfunction without necrosis. Extensive research elucidated mechanisms involving reactive oxygen species (ROS), calcium overload, and impaired excitation-contraction coupling. Recent advances in proteomics and phospho-proteomics identified molecular changes linked to contractile dysfunction, extracellular matrix damage, and apoptosis. The role of epigenetics has also garnered attention for its potential to influence myocardial stunning and offer therapeutic avenues. This review comprehensively explores the historical and mechanistic landscape of myocardial stunning, recent molecular insights, and its clinical relevance. Future research directions emphasize advanced proteomic and phosphor-proteomic analyses, epigenetic mechanisms, clinical translation, non-invasive diagnostics, ROS role clarification, ischemia preconditioning impacts, and integrative systems biology. Addressing these areas will enhance our understanding and lead to improved therapeutic strategies for ischemic heart disease.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.