Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Evaluation of physical rehabilitation in patients receiving curative treatment for head and neck cancer: The NUTRIMOUV randomized phase II trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02135185 (Phase II Study, Multicentric, Randomized Studying the Effect of the Rehabilitation Effort at Home in Patients With Head and Neck Tumor Treated With Curative Intent), which is not on this map. Not yet cited in PubMed.
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Phase II Study, Multicentric, Randomized Studying the Effect of the Rehabilitation Effort at Home in Patients With Head and Neck Tumor Treated With Curative Intent
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8 authors.
Funding
Abstract
purposePatients with head and neck squamous cell carcinoma (HNSCC) undergoing curative radiotherapy or chemoradiotherapy often experience adverse effects affecting physical and psychosocial health, which can lead to a deconditioning cycle, worsening side effects, treatment tolerance and quality of life. This multicenter phase II study evaluated whether physical rehabilitation combined with nutritional care could improve exercise tolerance and reverse the deconditioning cycle.
methodsPatients with localized HNSCC undergoing curative radiotherapy or chemoradiotherapy were randomized into two groups. One group engaged in a physical rehabilitation (PR) program, including quadriceps electrical stimulation three times a week during treatment, followed by three weekly sessions of home-based ergocycle training for 12 weeks, while the control (CT) group received standard care. Both groups received nutritional care. Success of the PR program was defined as a 40% increase in the patient's baseline endurance time or the ability of the patient to sustain the activity for 30 min at three months.
resultsSeventy patients were included, with 33 patients in the PR group. The success rate was higher in the PR group program (68%, CI 95% 48-84) than to the CT group (27%, CI 95% 16-48). From T0 to T2, the median endurance time changed by + 54% in PR vs. -55% in CT. No significant difference was observed regarding quality of life.
conclusionsOur results highlight that physical rehabilitation combined with nutritional care is feasible in this setting, and could improve exercise tolerance without modifying patient's quality of life. It emphasizes the crucial role of physical activity during cancer treatment. CLINICAL TRIAL REGISTRATION NUMBER: NCT02135185 on February 6, 2014 (retrospectively registered).
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