Evidence map›Paper›PMID 41401004›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Cilia-driven epithelial folding and unfolding in an early diverging animal.

Charlotte M Brannon, Manu Prakash

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cilia-driven epithelial folding and unfolding in an early diverging animal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Charlotte M BrannonDepartment of Biology, Stanford University, Stanford, CA 94305.
Manu PrakashDepartment of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0002-8046-8388

Funding

HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM007276National Science Foundation (NSF) N/aNSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE-2039655Schmidt Futures (Schmidt Futures Projects, LLC) N/aSU | Stanford Woods Institute for the Environment N/a
6 · The paper itself

Abstract

Multicellular organisms utilize epithelial folding to achieve remarkable three-dimensional forms. During embryonic development, stereotypical epithelial folds emerge from underlying active cellular and molecular processes including cell shape change and differential cell growth. However, the origin of epithelial folding in early animals and how folding may be harnessed in synthetic systems remain open questions. Here, we identify a modality of behavior-induced epithelial folding and unfolding arising from cilia-substrate adhesion and ciliary walking in the basal animal

Indexed as

CiliaPlacozoaAnimalsEpithelial CellsEpitheliumModels, Biologicalactive origamiciliaepithelial foldingPlacozoaTrichoplax adhaerens

Identifiers

PMID41401004
PMCPMC12745693

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.