Observational studyPloS one2025
Link between the albumin-corrected anion gap and 28 day all‑cause mortality among patients with sepsis complicated with chronic heart failure: A retrospective analysis using the eICU Collaborative Research Database.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThese two conditions, namely metabolic acidosis and hypoproteinemia, are prevalently observed in patients within intensive care units (ICU), particularly those with sepsis complicated with chronic heart failure. Nevertheless, the impact of the Albumin-Corrected Anion Gap (ACAG), an indicator reflecting the above conditions, on such patient mortality requires further investigation. This retrospective cohort study analyzed the significance of ACAG levels in forecasting 28-day all-cause mortality among these patients admitted to ICU.
methodsThis was observational cohort study on eICU Collaborative Research Database (eICU-CRD) that included in participants with sepsis complicated with chronic heart failure. In the study, we applied several methods such as multivariate Cox regression models and smooth curve fitting plots combined with Kaplan-Meier analysis to investigate how ACAG is correlated with 28 day all‑cause mortality. To explore the results' stability, subgroup analysis was performed and a forest plot was plotted.
resultsThe final analysis included 713 eligible participants after rigorous screening procedures. The mean level of ACAG was (16.68 ± 5.20) mmol/l. The 28-day mortality rate was 13.60% (97/713) in our study. The multivariate Cox regression analysis revealed a significant association between ACAG (as a continuous variable) and 28-day all-cause mortality, unadjusted model (HR 1.07, 95% CI 1.04-1.11, p < 0.0001), adjusted model 1 (HR 1.08, 95% CI 1.04-1,12, p < 0.0001), adjusted model II (HR, 1.08 (1.03,1.13), p < 0.001). After adjusting for all confounding factors (listed in the Model II), the smoothing curves showed a linear relationship. Mortality in such patients gradually increased with the increase of ACAG according to Kaplan-Meier analysis. Subgroup analysis illustrates the stability of the link between ACAG and 28-day mortality in participants with sepsis complicated with chronic heart failure across various subgroups.
conclusionsAfter adjusting for confounding factors, elevated ACAG is positively linked with increased 28-day mortality in patients with sepsis complicated with chronic heart failure.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.