ArticlePloS one2025
Association between the LDL/HDL ratio and sarcopenia in Chinese community-dwelling older adults.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
objectivesThe link between lipid disorders and diverse diseases is amply documented. Yet, research probing how serum lipid levels tie in with sarcopenia remains scarce. This study delves into the connection between the LDL/HDL ratio and sarcopenia among elderly Chinese people.
methodsA total of 3,968 senior participants from Chinese communities were included in this cross-sectional study. To explore the relationship between the LDL/HDL ratio and sarcopenia, both a multivariate logistic regression model and a restricted cubic spline model were used. ROC curve analysis was employed to gauge how well the LDL/HDL ratio can detect sarcopenia.
resultsAmong the participants, 780 were diagnosed with sarcopenia. Multivariable logistic regression unveiled a significant positive correlation between the LDL/HDL ratio and sarcopenia. After adjusting for potential confounders, each unit increase in the LDL/HDL ratio corresponded to an approximately 3-fold higher odds of sarcopenia (OR = 3.01, 95% CI: 2.66-3.41, P < 0.001). A non - linear relationship between the LDL/HDL ratio and sarcopenia was confirmed by RSC analysis (P < 0.001). ROC curve analysis showed that the LDL/HDL ratio outperformed its individual components in predictive ability for sarcopenia.
conclusionsThis study indicates that the LDL/HDL ratio may serve as an independent risk factor for sarcopenia.
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