Evidence map›Paper›PMID 41401588›Full record

ArticleInternational journal of hygiene and environmental health2026

Associations of glyphosate and aminomethylphosphonic acid (AMPA) concentrations with birth outcomes in pregnant women from the Midwestern U.S.

Kelsi A Morris, Maria E Cinzori, Brad A Ryva, Nicole Talge, Khyatiben V Pathak, Brooke Lovell, Patrick Pirrotte, Susan L Schantz, Rita S Strakovsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelsi A MorrisDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, 48824, USA.
Maria E CinzoriDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Brad A RyvaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA.
Nicole TalgeDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, 48824, USA.
Khyatiben V PathakEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA; Integrated Mass Spectrometry Shared Resource, City of Hope National Medical Center, CA, 85338, USA.
Brooke LovellEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA; Integrated Mass Spectrometry Shared Resource, City of Hope National Medical Center, CA, 85338, USA.
Patrick PirrotteEarly Detection and Prevention Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA; Integrated Mass Spectrometry Shared Resource, City of Hope National Medical Center, CA, 85338, USA.
Susan L SchantzDepartment of Comparative Biosciences, University of Illinois, Urbana-Champaign, IL, 61802, USA; Beckman Institute, University of Illinois, Urbana-Champaign, IL, 61801, USA.
Rita S StrakovskyDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, 48824, USA; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, 48824, USA. Electronic address: strakovs@msu.edu.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUH3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Andrea Aguiar, Susan L Schantz · 2018 to 2026
$18.6M
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
The Illinois Kids Development Study ECHO Pregnancy and Pediatric CohortUG3OD023272 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2016 to 2024
$7.2M
Project 3: Endocrine Disruptors and Diet: Effects on the Developing Cortex P01ES022848 · NIEHS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHANTZ, SUSAN L · 2013 to 2018
$4.2M
Reproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026
$2.5M
Exposure to phthalate mixtures in pregnancy and long-term consequences for maternal metabolic and hormonal statusR01ES032227 · NIEHS · MICHIGAN STATE UNIVERSITY · PI STRAKOVSKY, RITA S. · 2020 to 2025
$2.1M
RISK MANAGEMENT IN NATIVE AMERICAN COMMUNITIESR25ES007255 · NIEHS · CLARK UNIVERSITY (WORCESTER, MA) · PI GOBLE, ROBERT L · 1994 to 2002
$738k
NCI NIH HHS P30 CA033572NICHD NIH HHS T32 HD087166NIEHS NIH HHS P01 ES022848NIEHS NIH HHS R01 ES032227NIEHS NIH HHS R25 ES007255NIEHS NIH HHS T32 ES007255NIH HHS UG3 OD023272NIH HHS UH3 OD023272
6 · The paper itself

Abstract

backgroundPregnant women are ubiquitously exposed to the herbicide glyphosate and its major metabolite aminomethylphosphonic acid (AMPA). Therefore, we examined associations of glyphosate and AMPA with birth outcomes.

methodsPregnant women from the Illinois Kids Development Study (I-KIDS) participating in this pilot study (n = 300) provided first-morning urine samples at median 13-weeks gestation for glyphosate and AMPA measurement. We calculated gestational-age-at-birth using the last menstrual period after ultrasound confirmation, abstracted birthweight from electronic medical records, and calculated sex-specific birthweight-for-gestational-age z-scores (BWz). We measured birth length (cm) and anogenital distance (AGD) within 24 h of birth and calculated the anogenital index (AGI, mm/m) by dividing each AGD value (in mm) by the body length (in m). Multivariable linear regression models evaluated associations of glyphosate or AMPA with birth outcomes and differences in associations by newborn sex.

resultsIn all newborns, only 2-fold higher AMPA was associated with -0.07 cm shorter birth length (95 %CI: -0.16, 0.02). In males, each 2-fold higher glyphosate was associated with -0.06 lower BWz (95 % CI: -0.13, 0.01), -0.14 cm shorter birth length (95 %CI: -0.31, 0.04), and 0.63 longer AGI

conclusionsGlyphosate or AMPA were associated with smaller birth size and longer AGI

Indexed as

GlycineHerbicidesMaternal ExposureOrganophosphonatesPregnancy OutcomeAdultBirth WeightFemaleGestational AgeGlyphosateHumansIllinoisInfant, NewbornMalePilot ProjectsPregnancyaminomethylphosphonic acid (AMPA)GlycineGlyphosateHerbicidesOrganophosphonatesAminomethylphosphonic acidBirth outcomesGlyphosatePregnancy

Identifiers

PMID41401588
PMCPMC12781968

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.