ReviewCurrent opinion in structural biology2026
Recent breakthroughs in understanding the allosteric features of Ras GTPases and their effector and regulatory protein interactions, enabling drug design.
Review in Current opinion in structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Regulation of Membrane Association and Downstream Effector Interaction of K-Ras by Its Hypervariable Region.Membranes · 2026Article
- GDP-Loaded K-Ras Transiently Binds to Effector B-Raf RBD, Mirroring the Structure of the Active GTP-Loaded Complex.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ras guaosine triphosphate hydrolase (GTPase) are central to key cell signaling pathways and, when mutated, drive many cancers. Thought to be undruggable, dramatic progress has been made in the last decade in the design and screening of drugs, in large part thanks to an emerging detailed understanding of Ras conformational changes, excited/sparsely populated states, and allosteric interactions with ligands and protein-binding partners. This perspective reviews this recent progress and how it has been enabled by deep mutational scanning, solution nuclear magnetic resonance (NMR) spectroscopic studies, as well as computational modeling and simulations. We critically discuss these developments over the last 5 years, also for the GTPase-activating proteins (GAP) NF1 and plexin, effector proteins, plexin and Raf, and make suggestions on the gaps in our understanding that still exist.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.