Observational studyPediatric neurology2026
Six-Minute Activity-95
Observational study in Pediatric neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundThe six-minute walk test and quantitative muscle testing (QMT) are commonly used skeletal muscle assessments in Duchenne muscular dystrophy; however, they present challenges in nonambulatory patients. Our objective was to evaluate whether 6-min activity-95
methodsParticipants (N = 139) in an observational, longitudinal natural history study with median age of 12.0 years [interquartile range 10.0, 15.0] completed muscle testing and were instructed to wear an accelerometer on dominant wrist for 7 days and nights (a "wear") at each of three annual study visits. One hundred two male participants were analyzed with a total of 184 valid wear periods.
resultsSix-minute activity centiles declined over 2 years (n = 28, P < 0.001). No significant declines in centiles were detected immediately following loss of ambulation (n = 11). Significant correlations were observed between 6-min activity centiles and indexed QMT, with strongest at 95
conclusionsAmbulatory and nonambulatory patients with Duchenne muscular dystrophy were differentiated by 6-min activity and declined over time, modeling progression of skeletal myopathy. Six-minute activity-95
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.