Evidence map›Paper›PMID 41401974›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

Enteric glia, neuropeptides, and Parkinson's: impacts of calcitonin gene-related peptide on gut alpha synuclein.

Hayley N Templeton, Toby B Lanser, Stuart A Tobet, Luke A Schwerdtfeger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hayley N TempletonDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States.ORCID 0009-0009-4242-4120
Toby B LanserProgram in Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States.ORCID 0000-0002-2250-6075
Stuart A TobetDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States.ORCID 0000-0002-1615-7331
Luke A SchwerdtfegerDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States.ORCID 0000-0001-8030-3164

Funding

Sex Differences in Major Depression, Part II: Impact of Prenatal Immune, Autonomic and Neurovascular FunctionU54MH118919 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Ronald G. Garcia · 2020 to 2026
$12.7M
Foundation for Neurologic DiseasesHHS | NIH | National Institute of Mental Health (NIMH) ORWH NIMH U54-MH118919NIMH NIH HHS U54 MH118919
6 · The paper itself

Abstract

Parkinson's disease is a neurodegenerative disorder pathologically characterized by accumulation of misfolded α-synuclein in the central and peripheral nervous systems, influencing symptomology at both sites. Calcitonin gene-related peptide (CGRP), a neuropeptide produced in the brain and intestine, has been linked with altered α-synuclein aggregation. This study examines the role of calcitonin gene-related peptide in modulating enteric α-synuclein accumulation and enteric glial cell reactivity using an ex vivo slice culture model from A53T

Indexed as

alpha-SynucleinCalcitonin Gene-Related PeptideColonEnteric Nervous SystemNeurogliaNeuropeptidesParkinson DiseaseAnimalsHumansIntestinal MucosaMaleMiceMice, Inbred C57BLNeuronsalpha-SynucleinCalcitonin Gene-Related PeptideNeuropeptidesalpha synucleincalcitonin gene-related peptideenteric glial cellParkinson’s disease

Identifiers

PMID41401974
PMCPMC12933388

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.