Evidence map›Paper›PMID 41401977›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026

Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency.

Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Angelo D'Alessandro, Yongho Bae, Sachin A Gupte

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina SignorettiDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0002-0982-4976
Samuel FatehiDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.
Rhonda DrewesDepartment of Pathology and Anatomical Science, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, New York, United States.
Francesca CendaliDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-9947-2520
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-2258-6490
Yongho BaeDepartment of Pathology and Anatomical Science, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, New York, United States.ORCID 0000-0002-1838-1652
Sachin A GupteDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0001-7453-8303

Funding

Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL166546 · NHLBI · NEW YORK MEDICAL COLLEGE · PI SACHIN A GUPTE, Joseph M Miano · 2023 to 2026
$2.7M
Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and PathologyR01HL163168 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yongho Bae, Su Chin Heo · 2023 to 2026
$2.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL132574HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL163168HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL166546NHLBI NIH HHS R01 HL132574NHLBI NIH HHS R01 HL163168NHLBI NIH HHS R01 HL166546
6 · The paper itself

Abstract

Pulmonary fibrosis (PF) is a major cause of morbidity and mortality. Although increased oxidative stress and altered metabolism are implicated in PF pathobiology, our knowledge regarding the contribution of the glucose metabolism to the synthesis of extracellular matrix (ECM) is still incomplete. Therefore, our objective was to determine altered metabolic pathways that contribute to bleomycin (BLM; 5 mg/kg) sulfate-induced PF in rats. We determined the effects of nebulized BLM on PF in CRISPR-edited rats expressing glucose-6-phosphate dehydrogenase (G6PD) variant (S188F;

Indexed as

BleomycinGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyPulmonary FibrosisAnimalsExtracellular MatrixLungMaleNF-E2-Related Factor 2Oxidative StressRatsRats, Sprague-DawleyBleomycinGlucosephosphate DehydrogenaseNF-E2-Related Factor 2extracellular matrixfibrosismetabolismproteomicsspatial proteomics

Identifiers

PMID41401977
PMCPMC13657661

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.