ArticleScientific data2025
Comprehensive snRNA-Seq Datasets of Human and Mouse Podocytopathy Integrated with GWAS of Microalbuminuria.
Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Podocyte (POD) injury is a hallmark of glomerular diseases and a central cause of albuminuria and nephrotic syndrome. Despite the rapid advancements in single-cell sequencing technologies in recent years, POD capture remains limited, resulting in a lack of comprehensive single-cell datasets related to Podocytopathies (PCPs). In this study, we collected kidney tissues from patients with five types of PCP and established two mouse models of POD injury for single-nucleus RNA sequencing (sn-RNA seq). We successfully generated single-cell resolution kidney atlases of human and mouse PCPs and, in combination with microalbuminuria-associated genome wide association study (GWAS) dataset, identified potential therapeutic targets linked to POD injury. These findings provide valuable resources and a solid foundation for future research on PCPs, particularly on the molecular mechanisms underlying POD injury.
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