Evidence map›Paper›PMID 41402480›Full record

ArticleMolecular psychiatry2026

Disrupted Development of the mPFC-Thalamic Circuit in Shank3

Gabrielle Devienne, Gil Vantomme, John R Huguenard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gabrielle DevienneDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2204-8043
Gil VantommeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7441-0737
John R HuguenardDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. huguenard@stanford.edu.ORCID https://orcid.org/0000-0002-6950-1191

Funding

Chronic Axon Hypofunction in Maternal Immune Activation Models of Neurodevelopmental DisordersR01MH121075 · NIMH · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2020 to 2023
$1.9M
Chronic Axon Hypofunction in Maternal Immune Activation Models of Neurodevelopmental DisordersR56MH121075 · NIMH · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2019 to 2019
$486k
NIMH NIH HHS R01 MH121075NIMH NIH HHS R56 MH121075Simons Foundation 633450
6 · The paper itself

Abstract

Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders with heterogeneous causes, and are characterized by communication deficits, impaired social interactions, and repetitive behaviors. Despite numerous studies in mouse models focused on pathophysiological circuit mechanisms of ASD in mature animals, little is known regarding ASD onset and its evolution through development. The medial prefrontal cortex (mPFC) is crucial for higher-order cognitive functions and social behavior, thus key to understanding ASD pathology. To explore early developmental disruptions in the mPFC, we used the Shank3 knockout (Shank3

Indexed as

Nerve Tissue ProteinsPrefrontal CortexThalamusAnimalsAutism Spectrum DisorderAutistic DisorderDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsNeural PathwaysNeuronsSocial BehaviorMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse

Identifiers

PMID41402480
PMCPMC13541370

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.