ArticleBMC cardiovascular disorders2025
Association between stress hyperglycemia ratio and all-cause mortality in patients with coronary heart disease.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStress hyperglycemia ratio (SHR) has been associated with adverse clinical outcomes in hospitalized patients with acute coronary syndromes (ACS). However, its role in long-term prognosis remains controversial. This study aims to investigate the correlation between SHR and post-discharge all-cause mortality in coronary heart disease (CHD) patients.
methodsA retrospective cohort analysis was conducted on a comprehensive dataset encompassing 5,273 coronary heart disease (CHD) patients from The First Affiliated Hospital of Shantou University Medical College, spanning from January 2020 to April 2024. The study introduced a novel parameter, Stress hyperglycemia ratio (SHR), calculated using the formula: SHR =[Formula: see text]. Cox regression analysis, smooth curve fitting techniques, and subgroup analyses were employed to evaluate associations.
resultsDuring a maximum follow-up of 1,649 days, 8.1% of patients experienced all-cause mortality. After multivariable adjustments, a U-shaped association emerged between SHR and mortality risk (HR = 1.35, 95%CI= (1.03 ~ 1.77), P = 0.031). Both low and high SHR levels were linked to increased mortality.
conclusionsSHR demonstrates a U-shaped association with post-discharge all-cause mortality in CHD patients, highlighting the need for glycemic management within an optimal range.
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