Evidence map›Paper›PMID 41402949›Full record

ArticleBMC rheumatology2025

Lengthened telomere length in peripheral blood leukocytes in patients with rheumatoid arthritis complicated with airway disease.

Takashi Higuchi, Shomi Oka, Kota Shimada, Shinichiro Tsunoda, Satoshi Ito, Misuzu Fujimori, Tadashi Nakamura, Michita Suzuki, Koichiro Saisho, Satoshi Shinohara and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Takashi HiguchiDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.
Shomi OkaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.
Kota ShimadaDepartment of Rheumatology, NHO Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392, Japan.
Shinichiro TsunodaDivision of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan.
Satoshi ItoDepartment of Rheumatology, Niigata Rheumatic Center, 1-2-8 Hon-cho, Shibata, 957-8588, Japan.
Misuzu FujimoriDepartment of Rheumatology, NHO Himeji Medical Center, 68 Hon-machi, Himeji, 670- 8520, Japan.
Tadashi NakamuraDepartment of Rheumatology, Sakurajuji Hospital, 1-1-1 Miyukikibe, Minami-ku, Kumamoto, 861-4173, Japan.
Michita SuzukiDepartment of Internal Medicine, NHO Nagoya Medical Center, 4-1-1 Sannomaru, Naka- ku, Nagoya, 460-0001, Japan.
Koichiro SaishoDepartment of Orthopedics/Rheumatology, NHO Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo, 885- 0014, Japan.
Satoshi ShinoharaTochigi Rheumatology Clinic, 1-1-9 Ekimaedori, Utsunomiya, 321-0964, Japan.
Toshihiro MatsuiClinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392, Japan.
Kiyoshi MigitaClinical Research Center, NHO Nagasaki Medical Center, 2-1001-1 Kubara, Omura, 856-8562, Japan.
Shouhei NagaokaDepartment of Rheumatology, Yokohama Minami Kyosai Hospital, 1-21-1 Rokuura-higashi, Kanazawa-ku, Yokohama, 236-0037, Japan.
Shigeto TohmaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan.
Hiroshi FurukawaDepartment of Rheumatology, NHO Tokyo National Hospital, 3-1-1 Takeoka, Kiyose, 204-8585, Japan. furukawa-tky@umin.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPatients with rheumatoid arthritis (RA) frequently have complications including chronic lung diseases (CLDs) consisting of airway disease (AD) or interstitial lung disease (ILD) that confer a poor prognosis. Peripheral blood leukocyte telomere length is shortened in RA with ILD. Previous studies reported rare variants in telomerase genes that were deleterious were more frequent in RA with ILD compared with controls. However, these studies were conducted in European populations. Here, we investigated associations of telomere length with ILD or AD in Japanese RA.

methodsThe lengths of telomeres in 108 RA patients with usual interstitial pneumonia, 134 with nonspecific interstitial pneumonia, 236 with AD, 50 with emphysema and 425 without CLDs were measured by quantitative polymerase chain reaction.

resultsA significantly longer telomere length was observed in RA with AD (P = 0.0071). Multiple logistic regression analyses indicated the association of telomere length with AD remained (Padjusted=0.0029) when conditioned on TERT rs2736100, a single nucleotide variant related to AD in Japanese RA, and clinical characteristics, suggesting an independent association.

conclusionsWe report telomere length was independently associated with AD in Japanese RA patients.

Indexed as

Airway diseaseGenetic associationRheumatoid arthritisTelomere length

Identifiers

PMID41402949
PMCPMC12822175

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.