Evidence map›Paper›PMID 41403444›Full record

ArticleFrontiers in pharmacology2025

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of

Yiqun Dong, Zhaosen Fan, Xiaoxiao Li, Yucheng Ming, Dong Wang, Yuanda Song, Youpeng Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiqun Dong *Qilu Medical University, Zibo, Shandong, China.
Zhaosen Fan *Shandong Benon Biological Technology Co., Ltd., Jinan, Shandong, China.
Xiaoxiao LiShandong Engineering Research Center of Precision Nutrition and Healthy Aging, Qilu Medical University, Zibo, Shandong, China.
Yucheng MingShandong Engineering Research Center of Precision Nutrition and Healthy Aging, Qilu Medical University, Zibo, Shandong, China.
Dong WangShandong Engineering Research Center of Precision Nutrition and Healthy Aging, Qilu Medical University, Zibo, Shandong, China.
Yuanda SongShandong Engineering Research Center of Precision Nutrition and Healthy Aging, Qilu Medical University, Zibo, Shandong, China.
Youpeng FanShandong Engineering Research Center of Precision Nutrition and Healthy Aging, Qilu Medical University, Zibo, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study employs an integrated approach combining multi-omics analysis, network pharmacology, machine learning, and experimental validation to elucidate the molecular mechanisms of Methods: Asthma-related differentially expressed genes (DEGs) were identified from GEO datasets (GSE63142 and GSE14787). Weighted gene co-expression network analysis (WGCNA) was performed on GSE14787. Active ingredient targets of Results: Yielded 3,755 DEGs and the MEblack module correlated with asthma. Identified 1,317 potential targets, with 100 intersecting DEGs. Hub targets included HSP90AB1, CCNB1, CASP9, CDK6, NR3C1, ERBB2, and CCK. Strong binding affinities (e.g., carboxyatractyloside with HSP90AB1 at -10.09 kcal/mol) and stable complexes were confirmed. Immune profiling showed altered cell populations. Discussion:

Indexed as

asthmaFructus Xanthiiimmune infiltrationmachine learningmolecular dockingnetwork pharmacology

Identifiers

PMID41403444
PMCPMC12702957

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.