ArticleJournal of the American Heart Association2026
Blood-Brain Barrier Permeability Dynamics and Mediation of Triglyceride-Glucose Index on Acute Ischemic Stroke Outcomes.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion.CNS neuroscience & therapeutics · 2026Article
- Admission Inflammatory-Metabolic Biomarker Profiles and Outcome-Specific Prognostic Patterns After Endovascular Therapy for Acute Ischemic Stroke: A Multicenter Cohort Study.Journal of inflammation research · 2026Article
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evolution and severity of blood-brain barrier (BBB) permeability in the core and penumbra over time in acute ischemic stroke remain poorly understood. Recent studies have found that elevated triglyceride-glucose (TyG) index is associated with higher stroke recurrence, functional deterioration, and death. We investigated BBB permeability dynamics in patients with acute ischemic stroke and the impact of the BBB disruption-mediated TyG index on outcomes.
methodsThis double-centric retrospective study included patients with acute anterior large-artery occlusion from January 2019 to December 2023. BBB permeability was measured as flow extraction product (FED) values in the largest core and penumbra slices using computed tomography perfusion. The TyG index was calculated from triglyceride and glucose levels. Poor outcome was defined as a 90-day modified Rankin Scale score of 3 to 6. Linear correlation evaluated relationships between FED values, time, and TyG index. Logistic regression analyzed associations between FED, TyG index, and outcomes. Mediation analysis assessed BBB disruption's role in the insulin resistance-outcome relationship.
resultsThis study included 274 patients (median age, 67 years [interquartile range, 57-74]; 179 men [66%]). Penumbra FED values increased with time (
conclusionsFED values were higher in the core and increased over time, contributing to worse outcomes. An elevated TyG index mediates worse outcomes through increased BBB permeability, highlighting BBB stabilization as a potential therapeutic target.
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