ArticleJournal of the American Heart Association2026
Screening Patients for Elevated Left Ventricular End-Diastolic Pressure Using a Novel Noninvasive Brachial Cuff-ECG System: A Multicenter Validation Study.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Screening Patients for Elevated Left Ventricular End-Diastolic Pressure Using a Novel Noninvasive Brachial Cuff-ECG System: A Multicenter Validation Study.Journal of the American Heart Association · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeasurement of left ventricular end-diastolic pressure (LVEDP) is an established diagnostic method to evaluate heart failure but requires an invasive procedure. A noninvasive technique for detecting elevated LVEDP would improve the diagnosis of heart failure. Herein, we present the results of a multicenter study to validate a noninvasive system to detect elevated LVEDP.
methodsThe Vivio System includes a modified blood pressure cuff and single-lead ECG to capture brachial artery waveforms. A model was created to identify patients with elevated LVEDP (>18 mm Hg). For the invasive cohort, all patients were referred for coronary angiography and left heart catheterization for clinical indications. A group of 321 patients with no significant health problems were enrolled as a control cohort. Invasive LVEDP measurements were performed using Millar catheters. The training data set (n=262) contained 101 patients with LVEDP measurements (n=44 with LVEDP >18 mm Hg) and 161 controls. The validation data set (n=155) contained 75 patients with LVEDP measurements (n=40 with LVEDP >18 mm Hg) and 80 controls.
resultsLeave-one-out cross-validation on the training data set yielded a sensitivity of 0.84 (95% CI, 0.70-0.93]) and a specificity of 0.84 (95% CI, 0.79-0.89). The validation data set showed a sensitivity of 0.80 (95% CI, 0.64-0.91) and a specificity of 0.83 (95% CI, 0.75-0.90).
conclusionsThe Vivio System can accurately detect elevated LVEDP and has the potential to significantly improve early detection of heart failure in the outpatient setting.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.