ReviewClinical and translational allergy2025
Treatment of Hereditary Angioedema With Plasma-Derived C1 Inhibitor: A Review.
Review in Clinical and translational allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Treatment of Hereditary Angioedema With Plasma-Derived C1 Inhibitor: A Review.Clinical and translational allergy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE-C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE-nC1INH) have recently been classified, which occur due to different gene mutations. C1INH plays an integral role in the kallikrein-kinin system, where a deficiency of functional C1INH results in overproduction of bradykinin leading to subcutaneous and submucosal edema. Plasma-derived C1INH (pdC1INH) replacement therapy for hereditary angioedema has been in use clinically for over 40 years and has been developed for both intravenous and subcutaneous administrations. In this review, we provide an in-depth overview of the efficacy and safety of pdC1INH in clinical trials and real-world studies, and guideline recommendations for pdC1INH replacement therapy as a first-line treatment for on-demand therapy, short-term prophylaxis, and long-term prophylaxis in patients with HAE-C1INH Type 1 and 2, including special patient populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.