Evidence map›Paper›PMID 41405459›Full record

ArticleAntimicrobial agents and chemotherapy2026

Development of a high-throughput screening platform for

Ravi K R Marreddy, Nghi Nguyen, Chetna Dureja, Ann Marie McKelvey, Reid Powell, Abiola O Olaitan, Clifford Stephan, Julian G Hurdle

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Spermidine Synthase Gene as a Reporter of Transcription Inhibition inInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ravi K R MarreddyCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Nghi NguyenCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Chetna DurejaCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Ann Marie McKelveyCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Reid PowellCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Abiola O OlaitanCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.ORCID 0000-0003-2005-5706
Clifford StephanCenter for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.
Julian G HurdleCenter for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.ORCID 0000-0003-2214-8105

Funding

High Throughput Screening for Non-antibiotic inhibitors of Clostridium difficile PathophysiologyR01AI144459 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HURDLE, JULIAN G · 2019 to 2022
$2.4M
Cancer Prevention and Research Institute of Texas RP150578Cancer Prevention and Research Institute of Texas RP200668Division of Intramural Research, National Institute of Allergy and Infectious Diseases R01AI144459NIAID NIH HHS R01 AI144459
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsBacterial ToxinsClostridioides difficileEnterotoxinsHigh-Throughput Screening AssaysBacterial ProteinsHumansMicrobial Sensitivity TestsVirulenceAnti-Bacterial AgentsBacterial ProteinsBacterial ToxinsEnterotoxinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileassay developmentClostridioides difficileluciferasesmall-molecule inhibitor screeningtoxins

Identifiers

PMID41405459
PMCPMC12888876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.