ReviewBrain and behavior2025
Exploring the Animal Models of Gastrointestinal and Emotional Comorbidity.
Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Diet, gut microbiota, and the gut-brain axis: mechanistic interactions and therapeutic implications in neuropsychiatric disorders.Frontiers in cellular and infection microbiology · 2026Review
- Exploring the Animal Models of Gastrointestinal and Emotional Comorbidity.Brain and behavior · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundWith the comorbid anxiety/depression in gastrointestinal diseases occur at a high rate worldwide, it is particularly important to discover and optimize the protocols of comorbidity models, thus further to reveal the mechanism and develop the treatment strategies of comorbidity.
methodsUsing "functional dyspepsia (FD), animal model, anxiety, depression" as search terms, this search is conducted in PubMed, Web of Science, and SpringerLink databases, with the search period from 2020 to 2025.
resultsWe find that both iodoacetamide (IA) gavage and tail clamping (TC) are classical methods for establishing FD model; physical stress such as "ice water gavage" or "irregular feeding (IF)" also used. We propose that IA + TC + IF or TC + IF + ice water gavage can be used to prepare comorbidity models in future. Maternal separation (MS) may also potentially become one of the effective models for studying comorbidities. In anxiety/depression model, we show that both chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS) are classical models for emotional disorders. We suggest CRS/CUMS combines with IA/IF/TC can better to establish gastrointestinal-emotional comorbidity model which through brain-gut cross talk. Then the review also develops a comprehensive and standardized evaluation system for comorbidity models, with recording behavioral indicators related to gastrointestinal/emotional disorders, while including multidimensional parameters such as the microbiota, neuroinflammation, metabolomics, brain-gut peptide, and neurotransmitters.
conclusionThis study is the first comprehensive comparison of FD and anxiety-depression modeling protocols to propose effective protocols of comorbidity models and develop a comprehensive and standardized evaluation system for comorbidity models.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.