ReviewInflammation2025
Integrating Nutrition into Precision Medicine for Controlling Systemic Inflammation in Rheumatoid Arthritis.
Review in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of rheumatoid arthritis (RA) has evolved from the conventional “treat-to-target” approach to strategies that emphasize individualized, patient-centered care. Concepts such as “therapeutic matchmaking” and “smart-to-target” highlight the importance of biomarkers, comorbidities, and quality-of-life priorities in selecting treatments. There is increasing evidence that identifies the gut-joint axis as a critical factor in RA pathogenesis. This axis links gut microbiota composition, intestinal barrier integrity, and systemic inflammation. Dysbiosis, reduced short-chain fatty acid production, and increased gut permeability can lead to immune dysregulation and joint inflammation. Nutritional interventions, such as high-fiber diets, prebiotics, probiotics, polyphenols, and omega-3 fatty acids, can restore microbial balance, enhance barrier function, and reduce inflammation. Precision nutrition, which tailors dietary recommendations based on genetic, microbiome, metabolic, and lifestyle factors, provides a framework for incorporating gut health into RA management. Microbiome-guided dietary strategies may improve responses to pharmacologic treatments, enable early intervention, and provide preventive benefits for high-risk individuals. Combining personalized nutrition with pharmacotherapy could optimize disease control, mitigate side effects, and promote sustainable, patient-empowering care. Future research should focus on randomized controlled trials and advanced analytic tools to refine predictive models and establish personalized nutrition as a cornerstone of holistic RA management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.