Evidence map›Paper›PMID 41405992›Full record

ArticleCell reports2026

STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts.

Rayane Dennaoui, Madison N Wicker, Carson Moen, Michaela Schlederer, Kerry Vistisen, Aleata A Triplett, Thomas Rülicke, Hallgeir Rui, Lukas Kenner, Emilio Casanova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rayane DennaouiDepartment of Oncology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Madison N WickerDepartment of Oncology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Carson MoenDepartment of Oncology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Michaela SchledererDepartment of Pathology, Medical University of Vienna, Vienna, Austria.
Kerry VistisenDepartment of Oncology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
Aleata A TriplettEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Thomas RülickeDepartment of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Vienna, Austria.
Hallgeir RuiDepartment of Pharmacology, Physiology & Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lukas KennerDepartment of Pathology, Medical University of Vienna, Vienna, Austria; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria; Department of Molecular Biology, Umeå University, Umeå, Sweden.
Emilio CasanovaLudwig Boltzmann Institute for Hematology and Oncology, Vienna, Austria; Institute of Pharmacology, Center of Physiology and Pharmacology & Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Kay-Uwe WagnerDepartment of Oncology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA. Electronic address: kuwagner@wayne.edu.

Funding

TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · WAYNE STATE UNIVERSITY · 1985 to 2025
$1.0M
NCI NIH HHS R01 CA117930NCI NIH HHS R01 CA202917NCI NIH HHS T32 CA009531
6 · The paper itself

Abstract

Janus kinases 1 and 2 and STAT transcription factors are critical signaling nodes for numerous growth factors. In the mammary gland, JAK2 and STAT5a/b are essential for alveolar cell differentiation and lactation, but little is known about the cooperative roles of JAKs and STATs before pregnancy. We examined female mice conditionally deficient in JAK1/2 and discovered that both kinases jointly regulate epithelial cell proliferation and ductal morphogenesis. To assess the role of downstream STATs, we generated genetic models co-deficient in STAT3/5a/5b with or without STAT1 or JAK1. Although loss of STAT3/5a/5b leads to a JAK1-dependent upregulation of STAT1, the formation of mammary ducts is unaffected by the lack of expression and activation of all seven STAT proteins. Additionally, STAT deficiency impairs the cytokine-induced autophosphorylation of JAK1/2. These findings suggest that mammary duct development is orchestrated by STAT-independent signaling mechanisms of JAK1 and JAK2, potentially beyond their roles as tyrosine kinases.

Indexed as

Janus Kinase 1Janus Kinase 2Mammary Glands, AnimalSTAT Transcription FactorsAnimalsCell ProliferationEpithelial CellsFemaleMiceMice, KnockoutPhosphorylationSignal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorSTAT5 Transcription FactorJak1 protein, mouseJak2 protein, mouseJanus Kinase 1Janus Kinase 2STAT1 Transcription FactorSTAT3 Transcription FactorSTAT5 Transcription FactorSTAT Transcription Factorsconditional knockoutCP: cell biologyCP: developmental biologyCre recombinaseDNA-binding proteinsfemalegene targetinggrowth and developmentJAK1JAK2Janus tyrosine kinasesmammary gland developmentmorphogenesisprotein-tyrosine kinasesignal transductionSTAT proteins

Identifiers

PMID41405992
PMCPMC12990061

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.