Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Leanne M HoltNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0954-2298
Angelica Minier-ToribioNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-8860-5973
Rita FutamuraNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Caleb J BrowneNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0089-5433
Freddyson J Martínez-RiveraNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Tamara MarkovicNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Trevonn M GylesNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4635-5985
Szu-Ying YehNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eric M PariseNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-5364-5820
Matthew RiveraNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Corrine BrennerNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0009-0005-0334-8330
Yun Young YimNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-0061-6820
Veronika KondevNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-0860-9027
Molly EstillNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0009-0007-6322-6989
Shi YanDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0001-8486-7477
Eleanor KeaneNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1040-141X
Alexa LabancaNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1040-141X
Giselle RojasNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-8794-085X
Li ShenNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-5190-2851
Yan DongDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Eric J NestlerNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-7905-2000
Funding
Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 to 2025
$12.6M
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · YALE UNIVERSITY · 1985 to 2025
$2.1M
Molecular Studies of Cocaine Action in BrainR01DA007359 · NIDA · YALE UNIVERSITY · 1991 to 2025
$1.2M
Training Program in Substance Use DisordersT32DA053558 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$565k
Glial-mediated synaptic remodeling in drug addictionR01DA040620 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$547k
Cellular and Behavioral Function of Astrocytic Dopamine SignalingR01DA060868 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$446k
Investigation of the Molecular Mechanisms Underlying Astrocytic CREB's Regulation of Cocaine Drug-SeekingK01DA062014 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$181k
Transcriptional reprogramming of drug-associated memories in the nucleus accumbensK01DA054306 · UNIVERSITY OF FLORIDA · 2025 to 2025
Emerging evidence increasingly indicates that astrocytes are involved in neuropsychiatric disorders, including addiction, but the cocaine-induced astrocyte transcriptome has yet to be investigated. We performed RNA sequencing on whole-cell sorted astrocytes from the nucleus accumbens and bioinformatically characterized the astrocyte transcriptome following cocaine self-administration in male mice. We found that astrocytes exhibit robust and contextually specific transcriptional signatures that implicate adenosine 3',5'-monophosphate response element-binding protein (CREB) as a cocaine-induced transcriptional regulator in astrocytes. Cleavage under targets and release using nuclease sequencing (CUT&RUN) revealed increased astrocytic CREB DNA binding in response to cocaine. Viral-mediated manipulation of nucleus accumbens astrocytic CREB activity in combination with addiction-related behaviors revealed that astrocytic CREB increases the rewarding and reinforcing properties of cocaine. Furthermore, we identified potential molecular mechanisms of astrocytic CREB's influence through modulating astrocytic calcium dynamics and selectively increasing D1-type medium spiny neuronal activity.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Astrocytic CREB regulates transcriptomic, neuronal, and behavioral responses to cocaine. · full record | Socratic