Evidence map›Paper›PMID 41406402›Full record

ArticleNeurology2026

High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study.

Yufeng Du, Yan Borné, Jessica Samuelsson, Isabelle Glans, Xiaobin Hu, Katarina Nägga, Sebastian Palmqvist, Oskar Hansson, Emily Sonestedt

Abstract read
In one paragraph

Article in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yufeng DuDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, Gansu, China.
Yan BornéNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Sweden.
Jessica SamuelssonNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Sweden.
Isabelle GlansClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
Xiaobin HuDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, Gansu, China.
Katarina NäggaClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
Sebastian PalmqvistClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.ORCID 0000-0002-9267-1930
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.ORCID 0000-0001-8467-7286
Emily SonestedtNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe association between dairy intake and dementia risk remains uncertain, especially for dairy products with varying fat contents. The aim of this study was to investigate the association between high-fat and low-fat dairy intake and dementia risk.

methodsThis study used data from a prospective cohort in Sweden, the Malmö Diet and Cancer cohort, which consisted of community-based participants who underwent dietary assessment at baseline (1991-1996). Dietary intake was evaluated using a comprehensive diet history method that combined a 7-day food diary, a food frequency questionnaire, and a dietary interview. Dementia cases were identified through the Swedish National Patient Register until December 31, 2020, and cases diagnosed until 2014 were further validated. The primary outcome of the study was all-cause dementia, and the secondary outcomes were Alzheimer disease (AD) and vascular dementia (VaD). Cox proportional hazard regression models were used to estimate hazard ratio (HR) and 95% CI.

resultsThis study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78-0.97) and VaD (HR 0.71, 95% CI 0.52-0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among DISCUSSION: Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese, low-fat cream, and other dairy products showed no significant association.

Indexed as

Dairy ProductsDementiaDietary FatsDiet, High-FatAgedAlzheimer DiseaseCheeseCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSwedenDietary Fats

Identifiers

PMID41406402
PMCPMC12720290

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.