ArticlePhysiological research2025
Potential Effect of Trigonella Microgreens on Functional Parameters of HUVEC Cells in vitro.
Article in Physiological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
The growing popularity of microgreens is due to several health-promoting effects. Current evidence suggests a reduction in the risk of cardiovascular and neurodegenerative diseases, or anti-carcinogenic and anti-inflammatory effects. However, in vitro studies investigating cellular changes and molecular mechanisms are limited. Therefore, the use of various cell lines is required for a better understanding of microgreens' effects. In this study, the effect of Trigonella-foenum graecum L. microgreens (10 300 µg/mL) extract on morphological and functional changes in HUVEC cells were investigated. Basic cellular parameters such as mitochondrial activity (MTT assay), cell membrane integrity (CFDA-AM assay), and lysosomal activity (NR uptake) were evaluated after 24 h exposure to experimental ethanolic extract. In addition, the release of cytokine IL-6 was measured. Results revealed significant changes (p<0.05; p<0.01) in mitochondrial activity, followed by no defect in cell membrane integrity and non-significant changes in lysosomal activity of HUVEC cells. At the same time, some experimental doses of Trigonella slightly modulate IL-6 release, but showed no significant changes after 24 h exposure. Overall, our pilot study suggests the potential of Trigonella microgreens to modulate mitochondrial activity of HUVEC cells, without significant changes in cell membrane integrity, lysosomal activity, or IL-6 release. Key words Trigonella-foenum graecum L. " Microgreens " Cytokines " HUVEC cells.
Indexed as
Identifiers
41406488PMC12721813What Socratic holds
Registered trials
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