Evidence map›Paper›PMID 41406697›Full record

ArticleEnvironment international2026

Ultrafine particulate matter exposure induces gut microbiota dysbiosis together with ER stress in the liver and worsened atherosclerosis.

Rajat Gupta, Candace Chang, David H Gonzalez, Priyansha Srivastava, Collin Le, Daniel P Stefanko, Jocelyn A Castellanos, Mohamad Navab, Srinivasa T Reddy, Gregory A Fishbein and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rajat GuptaDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA; Environmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Candace ChangDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA; Environmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
David H GonzalezDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Environmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Priyansha SrivastavaDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Collin LeVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Daniel P StefankoDepartment of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Jocelyn A CastellanosDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Mohamad NavabDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Srinivasa T ReddyDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Environmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.
Gregory A FishbeinDepartment of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Constantinos SioutasUniversity of Southern California, Viterbi School of Engineering, Los Angeles, CA, USA.
Jonathan P JacobsEnvironmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Goodman-Luskin Microbiome Center, University of California Los Angeles, Los Angeles, CA, USA; Division of Gastroenterology, Hepatology and Parenteral Nutrition, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Tzung HsiaiDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Henry Samueli School of Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Jesus A AraujoDivision of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA; Environmental and Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: JAraujo@mednet.ucla.edu.

Funding

Dissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic ToxicityR01ES033703 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 to 2025
$1.0M
Novel Approaches for Improving Inflammation Resolution Following Chronic Exposure to Air PollutantsR01ES033660 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 to 2025
$887k
Interplay Between Macrophages, Lipid Oxidation and the Nrf2/HO-1 Axis in the Cardiometabolic Toxicity Induced by Ultrafine ParticlesR01ES032806 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$391k
CSRD VA IK2 CX001717NIEHS NIH HHS R01 ES029395NIEHS NIH HHS R01 ES032806NIEHS NIH HHS R01 ES033660NIEHS NIH HHS R01 ES033703
6 · The paper itself

Abstract

Air pollution exposure is associated with increased cardiovascular morbidity and mortality worldwide. Previous studies provide a causal relationship between exposure to particulate matter (PM) and atherosclerosis development. We have previously demonstrated increased aortic atherosclerosis and adverse metabolic effects in hyperlipidemic mice exposed to ambient ultrafine PM. However, the underlying mechanisms by which ambient PM promotes systemic effects leading to worsened atherosclerosis remain unknown. We have recently shown that the gut microbiota composition was altered in mice exposed to re-aerosolized PM in the ultrafine-size range for 10 weeks. We hypothesized that sub-chronic exposure to ultrafine PM induces gut dysbiosis in association with systemic prooxidative effects and atherosclerotic lesion development. Male apolipoprotein E knockout (ApoE

Indexed as

Air PollutantsAtherosclerosisDysbiosisEndoplasmic Reticulum StressGastrointestinal MicrobiomeParticulate MatterAnimalsLiverMaleMiceAir PollutantsParticulate MatterAtherosclerosisER stressGut microbiotaInflammationLipid peroxidationShort chain fatty acidsUltrafine particulate matter

Identifiers

PMID41406697
PMCPMC13372509

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.