Evidence map›Paper›PMID 41406949›Full record

Observational studyCell reports. Medicine2025

Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses.

Chen Lou, Guiquan Wang, Zuquan Xiong, Yingxin Celia Jiang, Yan Li, Ming Zhu, Haiyan Yang, Lin Wang, Liying He, Hsun-Ming Chang and 7 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chen LouReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; The First Clinical Medical College (School of Information and Engineering), Wenzhou Medical University, Wenzhou, China; Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Guiquan WangDepartment of Reproductive Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China; Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, China.
Zuquan XiongDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Yingxin Celia JiangCentenary Institute, The University of Sydney, Sydney, NSW, Australia.
Yan LiReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ming ZhuReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; The First Clinical Medical College (School of Information and Engineering), Wenzhou Medical University, Wenzhou, China.
Haiyan YangReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lin WangReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Liying HeReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Hsun-Ming ChangDepartment of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
Jia WangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Wencheng ZhuInstitute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Xi DongReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Terytty Yang LiState Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Laboratory of Longevity and Metabolic Adaptations, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China. Electronic address: teryttyliyang@fudan.edu.cn.
Shuai YuanDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. Electronic address: shuai.yuan@ki.se.
Yue ZhaoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center for Obstetrics and Gynecology, Beijing, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China. Electronic address: zhaoyue0630@163.com.
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: mu.liangshan@zs-hospital.sh.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at first birth, later menarche, higher estradiol, and sex hormone-binding globulin (SHBG) increase longevity, while pre-eclampsia liability decreases longevity. Older ages at first birth and at first sexual intercourse are associated with lower DNAmGrimAgeAccel, but these associations disappear after mutual adjustment. Mediation analyses identify cardiometabolic diseases, lung diseases, and mental disorders as key mediators. In corroborating the MR results, observational analyses show that early reproductive behaviors, such as age at first sex, are associated with accelerated biological aging. Additionally, we observe significant non-linear associations between hormone levels, age at menopause, and aging outcomes. This study highlights the impact of reproductive health on aging and suggests potential strategies for promoting healthy aging in women.

Indexed as

AgingReproductionAdultAgedFemaleHumansLongevityMendelian Randomization AnalysisMenopauseMiddle AgedPolymorphism, Single NucleotideSex Hormone-Binding GlobulinSex Hormone-Binding Globulinbiological agingfemale reproductive traitslongevityMendelian randomizationobservational analysis

Identifiers

PMID41406949
PMCPMC12765851

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.